zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-1104Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESСпектрофлуориметрический метод определения сукцината солифенацина в нефасованной и таблетированной формахSpectrofluorimetric Method for Determination of Solifenacin Succinate in Bulk and in Tablet FormulationSinghP.SinghP.

Чандигарх

Chandigarh

BaliА.BaliA.

Чандигарх

Chandigarh

alka.bali@rediffmail.comИнститут фармацевтических наук Центра перспективных исследований UGC, Панджабский университетUniversity Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University202228072022894593593Copyright © Singh P., Bali А., 20222022Singh P., Bali А.Singh P., Bali A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/1104

Разработан чувствительный, воспроизводимый и экономичный спектрофлуориметрический метод для количественного определения сукцината солифенацина в нефасованной и таблетированной формах. Метод проверен в соответствии с рекомендациями Международной конференции по гармонизации на линейность, точность, предел обнаружения, предел количественного определения и надежность. В области концентраций 15.0—95.0 мкг/мл отмечена отличная линейность с коэффициентом корреляции (r2) 0.9961. Пределы обнаружения и количественного определения 1.19 и 3.62 мкг/мл. С помощью предложенного метода показана хорошая извлекаемость лекарственного средства  из выпускаемой таблетированной формы.

A sensitive, reproducible, and cost-effective spectrofluorimetric method was developed for the quantification of solifenacin succinate in bulk and its tablet formulation. The method was validated in accordance with the International Conference on Harmonization guidelines with respect to linearity, accuracy, precision, limit of detection, limit of quantification, and robustness. Excellent linearity was noted in the concentration range of 15.0–95.0 μg/mL with a correlation coefficient (r2) of 0.9961. The limits of detection and quantitation for the proposed method were found to be 1.19 and 3.62 μg/mL, respectively. Excellent recovery  of the drug was obtained from its marketed tablet formulation with the proposed method.

спектрофлуориметрический методпредел обнаруженияпредел количественного определениясукцинат солифенацинаspectrofluorimetric methodlimit of detectionlimit of quantificationsolifenacin succinateWe sincerely thank Cipla Ltd., Mumbai (India) for graciously providing us with the pure samples of solifenacin succinate. This work was supported by the University Grants Commission (UGC), New Delhi, India (Grant No. 36/N/296).ReferencesD. Robinson, L. Cardozo, Expert Rev. Clin. Pharmacol., 2, No. 3, 239–253 (2009).D. Robinson, L. Cardozo, Expert Rev. Clin. Pharmacol., 2, No. 3, 239–253 (2009).R. Basra, C. Kelleher, Ther. Clin Risk Manag., 4, No. 1, 117–128 (2008).R. Basra, C. Kelleher, Ther. Clin Risk Manag., 4, No. 1, 117–128 (2008).D. Robinson, L. Cardozo, Therapy, 8, No. 6, 691–701 (2011).D. Robinson, L. Cardozo, Therapy, 8, No. 6, 691–701 (2011).N. Desai, S. S. Hussen, K. Arumugam, S. G. Vasanthraju, K. Udupan, Int. J. Pharm. Pharm. Sci., 3, No. 1, 70–74 (2011).N. Desai, S. S. Hussen, K. Arumugam, S. G. Vasanthraju, K. Udupan, Int. J. Pharm. Pharm. Sci., 3, No. 1, 70–74 (2011).R. Reddy, R. Sidhaye, A. Sherikar, M. Nadre, M. Krishna, Pharmacophore, 8, No. 2, 11–23 (2017).R. Reddy, R. Sidhaye, A. Sherikar, M. Nadre, M. Krishna, Pharmacophore, 8, No. 2, 11–23 (2017).R. P. Shaik, S. B. Puttagunta, C. K. Bannoth, B. S. R. Challa, ISRN Anal. Chem, 1–5 (2014).R. P. Shaik, S. B. Puttagunta, C. K. Bannoth, B. S. R. Challa, ISRN Anal. Chem, 1–5 (2014).V. Bhavana, H. T. Kumar, S. Y. Rao, V. P. K. Rao, Asian J. Pharm. Anal., 9, No. 3, 118–122 (2019).V. Bhavana, H. T. Kumar, S. Y. Rao, V. P. K. Rao, Asian J. Pharm. Anal., 9, No. 3, 118–122 (2019).M. C. Damle, P. C. Rokade, Int. J. Pharm. Sci. Res., 8, No. 4, 218–222 (2016).M. C. Damle, P. C. Rokade, Int. J. Pharm. Sci. Res., 8, No. 4, 218–222 (2016).S. R. Krishna, B. M. Rao, N. S. Rao, J. Chromatogr. Sci., 48, No. 10, 807–810 (2010).S. R. Krishna, B. M. Rao, N. S. Rao, J. Chromatogr. Sci., 48, No. 10, 807–810 (2010).H. Terada, Y. Hattori, T. Sasaki, M. Otsuka, Int. J. Pharm., 565, 325–332 (2019).H. Terada, Y. Hattori, T. Sasaki, M. Otsuka, Int. J. Pharm., 565, 325–332 (2019).B. Rakesh, P. Bhargavi, S. R. Reddy, A. A. Kumar, Int. J. Pharm. Pharm. Sci., 6, No. 10, 190–193 (2014).B. Rakesh, P. Bhargavi, S. R. Reddy, A. A. Kumar, Int. J. Pharm. Pharm. Sci., 6, No. 10, 190–193 (2014).K. M. Madhu, C. Rambabu, Rasayan J. Chem., 10, No. 4, 1068–1074 (2017).K. M. Madhu, C. Rambabu, Rasayan J. Chem., 10, No. 4, 1068–1074 (2017).L. Singh, L. S. Nanda, Pharm. Methods, 2, No. 1, 21–24 (2011).L. Singh, L. S. Nanda, Pharm. Methods, 2, No. 1, 21–24 (2011).G. D. Teja, C. D. Dasu, B. P. Srinivasa, P. Ravisankar, J. Chem. Pharm. Sci., 6, No. 3, 195–198 (2013).G. D. Teja, C. D. Dasu, B. P. Srinivasa, P. Ravisankar, J. Chem. Pharm. Sci., 6, No. 3, 195–198 (2013).P. Dhara, N. Saiyed, S. Desai, Int. J. Pharm. Pharm. Res., 2, No. 4, 175–183 (2015).P. Dhara, N. Saiyed, S. Desai, Int. J. Pharm. Pharm. Res., 2, No. 4, 175–183 (2015).Y. Srinivasarao, H. Kumar, P. Chiranjivi, V. K. Rao, Indian J. Pharm. Sci., 83, No. 2, 331–335 (2021).Y. Srinivasarao, H. Kumar, P. Chiranjivi, V. K. Rao, Indian J. Pharm. Sci., 83, No. 2, 331–335 (2021).B. V. Reddy, B. S. Reddy, N. V. V. S. S. Raman, K. S. Reddy, C. Rambabu, J. Chem., 1–10 (2013).B. V. Reddy, B. S. Reddy, N. V. V. S. S. Raman, K. S. Reddy, C. Rambabu, J. Chem., 1–10 (2013).D. Desai, G. Patel, N. Shukla, S. Rajput, Acta Chromatogr., 24, No. 3, 399–418 (2012).D. Desai, G. Patel, N. Shukla, S. Rajput, Acta Chromatogr., 24, No. 3, 399–418 (2012).M. A. Tantawy, S. A. Weshahy, M. Wadie, M. R. Rezk, Anal. Methods, 12, No. 26, 3368–3375 (2020).M. A. Tantawy, S. A. Weshahy, M. Wadie, M. R. Rezk, Anal. Methods, 12, No. 26, 3368–3375 (2020).D. K. Singh, M. Kurmi, T. Handa, S. Singh, Chromatographia, 79, No. 3-4, 159–168 (2016).D. K. Singh, M. Kurmi, T. Handa, S. Singh, Chromatographia, 79, No. 3-4, 159–168 (2016).J. Macek, P. Ptáček, J. J. Klíma, J. Chromatogr. B, 878, No. 31, 3327–3330 (2010).J. Macek, P. Ptáček, J. J. Klíma, J. Chromatogr. B, 878, No. 31, 3327–3330 (2010).W. G. Ammari, Trop. J. Pharm. Res., 14, No. 5, 845–851 (2015).W. G. Ammari, Trop. J. Pharm. Res., 14, No. 5, 845–851 (2015).T. C. Akman, Y. Kadıoğlu, Bioorg. Med. Chem., 2, 15–23 (2019).T. C. Akman, Y. Kadıoğlu, Bioorg. Med. Chem., 2, 15–23 (2019).T. Yanagihara, T. Aoki, Y. Soeishi, T. Iwatsubo, H. Kamimura, J. Chromatogr. B, 859, No. 2, 241–245 (2007).T. Yanagihara, T. Aoki, Y. Soeishi, T. Iwatsubo, H. Kamimura, J. Chromatogr. B, 859, No. 2, 241–245 (2007).S. B. Puttagunta, R. P. Shaik, C. K. Bannoth, B. S. R. Challa, B. Z. Awen, J. Anal. Sci. Technol., 5, No. 1, 1–8 (2014).S. B. Puttagunta, R. P. Shaik, C. K. Bannoth, B. S. R. Challa, B. Z. Awen, J. Anal. Sci. Technol., 5, No. 1, 1–8 (2014).ICH, Validation of analytical procedures: text and methodology Q2 (R1), In International Conference on Harmonization, Geneva, Switzerland 11, 1–13 (2005).ICH, Validation of analytical procedures: text and methodology Q2 (R1), In International Conference on Harmonization, Geneva, Switzerland 11, 1–13 (2005).

The authors declare that there are no conflicts of interest present.