References

zhps

Журнал прикладной спектроскопии

Zhurnal Prikladnoii Spektroskopii

0514-7506

B. I. Stepanov Institute of Physics of the National Academy of Sciences

zhps-117

Research Article

***

СПЕКТРОФОТОМЕТРИЧЕСКОЕ ОПРЕДЕЛЕНИЕ РИФАМПИЦИНА В ОБЪЕМНОЙ ЛЕКАРСТВЕННОЙ ФОРМЕ НА ОСНОВЕ РЕДОКСА И ОБРАЗОВАНИЯ КОМПЛЕКСОВ

SPECTROPHOTOMETRIC DETERMINATION OF RIFAMPICIN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS BASED ON REDOX AND COMPLEXATION REACTIONS

Swamy

N. .

Swamy

N. .

noemail@neicon.ru

Basavaiah

K. .

Basavaiah

K. .

kanakapurabasavaiah@gmail.com

Университет МайсyрРоссияUniversity of MysoreRussian Federation

2017

10032020

844

669(1)-669(10)

2020

Swamy N..., Basavaiah K...

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://zhps.ejournal.by/jour/article/view/117

Разработаны и протестированы два спектрофотометрических метода определения рифампицина (RIF) в объеме, составе и отдельной порции человеческой урины. Первый метод основан на восстановлении реагента Folin-Ciocalteu (FC) RIF с образованием синего хромогена с lmax = 760 нм (метод FCR). Во втором методе железо(III) восстанавливают с помощью RIF в нейтральной среде; полученное железо(II) образует комплекс с феррицианидом с максимумом l = 750 нм (метод FFC). В оптимальных условиях методы FCR и FFC позволяют определить концентрацию препарата в диапазонах 1-35 и 2.5-50 мкг/мл с молярной поглощательной способностью 2.72×104 и 1.63×104 л/(моль × см). Оценены чувствительность Санделла, пределы детектирования (LOD) и измерения (LOQ). Точность методов (погрешность <2%) удовлетворительная. Предложенные методы успешно использованы для определения лекарства в капсулах и человеческой моче. Статистический анализ показывает отсутствие существенных различий между результатами, полученными разработанными методами и официально используемым методом.

Two spectrophotometric methods were developed and validated for the determination of rifampicin (RIF) in bulk form, formulations, and spiked human urine. The first method is based on the reduction of the Folin-Ciocalteu (FC) reagent by RIF to form a blue colored chromogen with lmax at 760 nm (the FCR method). In the second method, iron(III) is reduced by RIF in a neutral medium, and the resulting iron(II) is complexed with ferricyanide to form a Prussian blue peaking at 750 nm (the FFC method). Under optimum conditions, Beer’s law enabled the determination of the drug in the concentration ranges 1-35 and 2.5-50 µg/mL with apparent molar absorptivities of 2.72×104 and 1.63×104 L/(mol × cm) for the FCR and FFC methods, respectively. The Sandell sensitivity, limits of detection (LOD), and quantification (LOQ) values were also reported for both methods. The precision of the methods, with % RSD of < 2%, was satisfactory, and the accuracy was higher than 2% (RE). The proposed methods were successfully applied to the determination of drug in capsules without interference from common additives and spiked human urine without interference from endogenous substances. A statistical analysis indicated that there was no significant difference between the results obtained by the developed methods and the official method.

рифампицинанализспектрофотометрияреагент FCферрицианидrifampicinassayspectrophotometryFC reagentferricyanide

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The authors declare that there are no conflicts of interest present.