zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-1368Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESОпределение вилдаглиптина с помощью простого и чувствительного флуоресцентного зондаDetermination of Vildagliptin Using a Simple and Sensitive Fluorescent ProbeJiaJ.JiaJ.

Байчэн, Цзилинь

Baicheng, Jilin

LiuM.LiuM.

Чанчунь

Changchun

liumei@ccut.edu.cnLiuL.LiuL.

Чанчунь

Changchun

Химический колледж Байчэнского педагогического университетаCollege of Chemistry, Baicheng Normal UniversityШкола химии и естественных наук Института материаловедения, Чанчуньский технологический университетSchool of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of TechnologyИнститут химической и промышленной биоинженерии Цзилиньского инженерно-педагогического университетаInstitute of Chemical and Industrial Bioengineering, Jilin Engineering Normal University202328082023904657657Copyright © Jia J., Liu M., Liu L., 20232023Jia J., Liu M., Liu L.Jia J., Liu M., Liu L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/1368

Вилдаглиптин (VLG), препарат для лечения диабета второго типа, не флуоресцирует в водном растворе, что затрудняет его определение прямыми флуориметрическими методами. Предложен конкурентный метод флуориметрического обнаружения VLG с использованием CB[7]–BER (кукурбит[7]урил = CB[7], BER = берберин) в качестве флуоресцентного зонда. Показана хорошая корреляция метода в диапазоне концентраций 0.00213–1.820 мкг/мл с коэффициентом r2 > 0.999. Для флуоресцентного зонда CB[7]–BER предел обнаружения 0.64 нг/мл. Метод успешно применен для определения VLG в фармацевтических препаратах и синтетической урине.

Vildagliptin (VLG), a drug for the treatment of type 2 diabetes, is nonfluorescent in aqueous solution. This property makes it difficult to determine by direct fluorometric methods. We proposed a new competitive method for fluorometric detection of VLG using CB[7]–BER (cucurbit[7]uril = CB[7], BER = berberine) as a fluorescent probe. The method showed a good calibration curve within the concentration range 0.00213– 1.820 mg/mL with an excellent correlation coefficient (r2 >0.999). The detection limit is 0.64 ng/mL for CB[7]–BER fluorescent probe. Moreover, the method was successfully applied for the determination of VLG in pharmaceutical tablets and artificial urine. To our knowledge, this is the first example of determining VLG using a fluorescent probe method.

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The authors declare that there are no conflicts of interest present.