zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-1437Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESКинетический спектрофотометрический метод определения цефтриаксона в нерасфасованном виде и во флаконахKinetic Spectrophotometric Method for Determination of Ceftriaxone in Bulk and VialsYosreyЕ.YosreyE.

Эль-Мансура

Eman Yosrey

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Mansoura

emanyosrey435@gmail.comElmansiH.ElmansiH.

Эль-Мансура

Heba Elmansi

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Mansoura

SheribahZ. А.SheribahZ. A.

Эль-Мансура

Zeinab A. Sheribah

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Mansoura

El-Sayed MetwallyM.El-Sayed MetwallyM.

Эль-Мансура

Mohammed El-Sayed Metwally

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy

Mansoura

Университет Эль-МансурыMansoura University202325112023906973973Copyright © Yosrey Е., Elmansi H., Sheribah Z.А., El-Sayed Metwally M., 20232023Yosrey Е., Elmansi H., Sheribah Z.А., El-Sayed Metwally M.Yosrey E., Elmansi H., Sheribah Z.A., El-Sayed Metwally M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/1437

Разработан сверхчувствительный кинетический спектрофотометрический метод определения цефтриаксона. Каталитическое поведение препарата использовано для ускорения реакции между иодом и азидом натрия. Метод фиксированного времени применен для выбора оптимального времени реакции, которое составляет 7 мин после добавления иода при рН 2.0 с использованием 0.1 М фосфатного буфера. Изучены и оптимизированы экспериментальные параметры, влияющие на образование продукта реакции. Валидация метода в соответствии с рекомендациями ICH показала линейность в пределах 0.25–2.50 мкг/мл при 348 нм. Исследована кинетика реакции и рассчитана константа скорости реакции. Метод успешно применен для анализа препарата в лекарственных формах с высокой селективностью. Сравнение результатов разработанного подхода и предложенного ранее спектрофотометрического метода не показало существенной разницы в отношении точности и прецизионности, чувствительность разработанного метода в 20 раз больше.

An ultra-sensitive kinetic spectrophotometric method has been carried out to determine ceftriaxone in a simple and cost-effective manner. The method utilized the catalytic behavior of the drug in accelerating the reaction between iodine and sodium azide. The fixed time method was exploited to select the optimum reaction time and it was found to be 7.0 minutes after the addition of iodine at pH 2.0 using 0.1 M phosphate buffer. Experimental variables that affect the formation of the reaction product were studied and optimized. The method was validated following ICH guidelines and showed excellent linearity within 0.25–2.50 μg/mL at 348 nm. Kinetics of the reaction were investigated and the reaction rate constant was calculated. The method was successfully applied for the analysis of the drug in dosage forms with high selectivity. Comparing the results of the developed approach with the results of the reported spectrophotometric method showed no significant difference with respect to accuracy and precision. The developed method reached a sensitivity 20 folds greater than the reported method. Being selective and sensitive in analysis makes the method a suitable candidate for quality control monitoring of the cited drug.

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The authors declare that there are no conflicts of interest present.