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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zhps</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал прикладной спектроскопии</journal-title><trans-title-group xml:lang="en"><trans-title>Zhurnal Prikladnoii Spektroskopii</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-7506</issn><publisher><publisher-name>B. I. Stepanov Institute of Physics of the National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">zhps-1536</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABSTRACTS ENGLISH-LANGUAGE ARTICLES</subject></subj-group></article-categories><title-group><article-title>азработка и валидация спектрофотометрического метода определения эмпаглифлозина в форме активного фармацевтического ингредиента и таблеток</article-title><trans-title-group xml:lang="en"><trans-title>Spectrophotometric Method Development and  Validation of Empagliflozin in Active Pharmaceutical Ingredient and Tablet Dosage Form</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Sahu</surname><given-names>S.</given-names></name><name name-style="western" xml:lang="en"><surname>Sahu</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Текари Райпур</p></bio><bio xml:lang="en"><p>Tekari Raipur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pandey</surname><given-names>R. K.</given-names></name><name name-style="western" xml:lang="en"><surname>Pandey</surname><given-names>R. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Текари Райпур</p></bio><bio xml:lang="en"><p>Tekari Raipur</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Shukla</surname><given-names>S. S.</given-names></name><name name-style="western" xml:lang="en"><surname>Shukla</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Текари Райпур</p></bio><bio xml:lang="en"><p>Tekari Raipur</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Gidwani</surname><given-names>B.</given-names></name><name name-style="western" xml:lang="en"><surname>Gidwani</surname><given-names>Bina</given-names></name></name-alternatives><bio xml:lang="ru"><p>Текари Райпур</p></bio><bio xml:lang="en"><p>Tekari Raipur</p></bio><email xlink:type="simple">beenagidwani@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Отделение фармацевтической химии Колумбийского фармацевтического института</institution></aff><aff xml:lang="en"><institution>Department of Pharmaceutical Chemistry, Columbia Institute of Pharmacy</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Отделение фармакогнозии Колумбийского фармацевтического института</institution></aff><aff xml:lang="en"><institution>Department of Pharmacognosy, Columbia Institute of Pharmacy</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Отделение обеспечения фармацевтического качества Колумбийского фармацевтического  института</institution></aff><aff xml:lang="en"><institution>Department of Pharmaceutical Quality Assurance, Columbia Institute of Pharmacy</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>04</month><year>2024</year></pub-date><volume>91</volume><issue>2</issue><fpage>311</fpage><lpage>311</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Sahu S., Pandey R.K., Shukla S.S., Gidwani B., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Sahu S., Pandey R.K., Shukla S.S., Gidwani B.</copyright-holder><copyright-holder xml:lang="en">Sahu S., Pandey R.K., Shukla S.S., Gidwani B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zhps.ejournal.by/jour/article/view/1536">https://zhps.ejournal.by/jour/article/view/1536</self-uri><abstract><p>Эмпаглифлозин, ингибитор SGLT-2, натрий-зависимый котранспортер глюкозы, обнаруживается главным образом в проксимальных канальцах нефронического компонента почек. Эмпаглифлозин в таблетированной форме проанализирован с помощью УФ-спектрофотометрии. При разработке и валидации метода определения эмпаглифлозина в качестве растворителя использован метанол. Максимальная длина волны поглощения раствора определена с помощью УФ-спектрофотометра, поглощение измерено с использованием различных калибровочных стандартов. Рассчитаны диапазон линейности калибровочной зависимости концентрации от оптической плотности. Определены точность, прецизионность, предел обнаружения, предел количественного определения  и надежность аналитического подхода. Коэффициент корреляции 0.999 указывает на линейность в диапазоне концентраций 2–10 мкг/мл. Максимальное поглощение эмпаглифлозина в метаноле регистрируется на 238.5 нм. Извлечение оценивалось в соответствии с принципами Международной конференции по гармонизации и соответствовало допустимым пределам (93.25%). Разработанный УФ-спектрофотометрический метод показал точность с относительным стандартным отклонением &lt;2%. </p></abstract><trans-abstract xml:lang="en"><p>Empagliflozin, an inhibitor of SGLT-2, a sodium glucose co-transporter is found mainly in the proximal tubules of the nephronic components of the kidney. The assay of empagliflozin in its tablet form has been created using a unique, secure, and sensitive UV-spectrophotometric approach. During the development and validation of the method for the assay of empagliflozin, methanol was employed as the solvent. The maximum absorbance wavelength of the solution was determined by scanning in a UV spectrophotometer. At the specified wavelength; absorbance was measured using a variety of calibration standards. The linearity and range of the calibration curve of concentration vs. absorbance were computed. The accuracy, precision, limit of detection, limit of quantitation, and ruggedness of the analytical approach were among the metrics that were determined. A correlation coefficient of 0.999 indicated linearity within the concentration range  2–10 µg/mL. The maximum absorbance of empagliflozin in methanol was determined to be 238.5 nm. Recovery was estimated as per International Conference on Harmonization guidelines and was found to be as per the acceptance limits: 93.25%. The developed UV method was found to be precise with relative standard deviation less than 2%. The assessment of empagliflozin in its tablet formulation using a UVspectrophotometric technique was determined to be both safe and helpful. The uniqueness of this research is based on a costefficient, time-saving, safe, easy, and successful approach for validating empagliflozin. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>валидация</kwd><kwd>таблетка</kwd><kwd>спектроскопия</kwd><kwd>эмпаглифлозин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>validation</kwd><kwd>tablet</kwd><kwd>spectroscopy</kwd><kwd>empagliflozin</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">The authors acknowledge Department of Science and Technology (DST-FIST) Letter no-SR/FST/COLLEGE/2018/418, New Delhi, for providing financial assistance.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">G. Chawla, K. A. Chaudhary, Diabetes &amp; Metabolic Syndrome: Clin. Res. Rev., 13, 2001–2008 (2019).</mixed-citation><mixed-citation xml:lang="en">G. Chawla, K. A. 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