zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-1728Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESКоличественное определение апрепитанта с помощью реакций комплексообразования с переносом заряда и методов видимой спектрофотометрииQuantification of aprepitant via charge transfer complexation reactions through visible spectrophotometric methodsChaitanyaM.ChaitanyaM.

Саидабад, Хайдарабад, Телангана

Saidabad, Hyderabad, Telangana

KumarT. H.KumarT. Hemant

Ширпур

Shirpur

hemkar_pharma@yahoo.co.inKoduruS.KoduruS.

Саидабад, Хайдарабад, Телангана

Saidabad, Hyderabad, Telangana

KalepuS.KalepuS.

Саидабад, Хайдарабад, Телангана

Saidabad, Hyderabad, Telangana

Фармацевтический женский колледж имени Боджама Нарасимлу Винай НагарDepartment of Pharmaceutical Analysis, Bojjam Narasimhlu College of Pharmacy for Women Vinay NagarШкола фармацевтических технологий и управления NMIMSDepartment of Quality Assurance, School of Pharmacy Technology and Management NMIMS202418112024916922922Copyright © Chaitanya M., Kumar T., Koduru S., Kalepu S., 20242024Chaitanya M., Kumar T., Koduru S., Kalepu S.Chaitanya M., Kumar T., Koduru S., Kalepu S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/1728

Для обнаружения апрепитантов в фармацевтических дозировках разработаны два спектрофотометрических подхода, основанных на процессах комплексообразования с переносом заряда. В методе A апрепитант реагирует с парахлораниловой кислотой в ацетонитриле, что приводит к образованию продукта фиолетового цвета. Этот продукт показал максимальную поглощательную способность при длине волны 524 нм. В методе B сочетание апрепитанта и пикриновой кислоты в хлороформе приводит к образованию хромофоров желтой окраски с максимальной поглощательной способностью при 415 нм. Каждый экспериментальный параметр изучен и настроен для оптимизации развития цвета. Оценены свойства рекомендуемых спектрофотометрических подходов, в том числе линейность, диапазон, точность, достоверность, специфичность, надежность. В диапазоне концентраций 10–60 мкг/мл оба подхода показали линейную зависимость с высокими коэффициентами корреляции. 

Two spectrophotometric approaches based on charge transfer complexation processes were developed, validated, and deployed for the detection of aprepitants in pharmaceutical dosages. In method A, the aprepitant reacts para chloranilic acid (p-CA) in acetonitrile, resulting in the formation of a purple-colored product. This product exhibited a maximum absorbance at a wavelength of 524 nm. In technique B, the combination of aprepitant and picric acid (PA) in chloroform results in the generation of chromophores having yellow coloration with a peak absorbance at 415 nm. Every experimental parameter was thoroughly examined and fine-tuned to optimize color development. The validation properties of the recommended spectrophotometric approaches, including linearity, range, precision, accuracy, specificity, robustness, detection, and quantification restrictions, were effectively evaluated. Within the concentration range of 10–60 μg/mL, both approaches exhibited a linear relationship with high correlation coefficient values. The suggested that the processes for quantifying aprepitants in dosage form are straightforward, rapid, precise, accurate, and costeffective. 

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The authors declare that there are no conflicts of interest present.