zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-1823Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESАнализ телмисартана в образцах таблеток после истечения срока годности с помощью УФ-спектроскопииAnalysis of Telmisartan Using UV Spectroscopy in Marketed Samples Post Shelf-LifeKuttyS. V.KuttySheeja Velayudhan

Палаккад, Керала

Palakkad (Kerala)

sheejasureshsree@yahoo.comFasnaM. A.FasnaM. A.

Палаккад, Керала

Palakkad (Kerala)

HamsaN. K.HamsaNesiya Kunnath

Палаккад, Керала

Palakkad (Kerala)

ShukoorC. A.ShukoorC. Abdul

Палаккад, Керала

Palakkad (Kerala)

AjmalT.I. M.AjmalT. I. Muhamad

Палаккад, Керала

Palakkad (Kerala)

MachadoJ.MachadoJikhila

Палаккад, Керала

Palakkad (Kerala)

MeghaG.MeghaG.

Палаккад, Керала

Palakkad (Kerala)

DivyaV.DivyaV.

Палаккад, Керала

Palakkad (Kerala)

Университет медицинских наук Кералы, Фармацевтический колледж ГрейсKerala University of Health Sciences, Grace College of Pharmacy (Department of Pharmaceutical Analysis)202528032025922266266Copyright © Kutty S.V., Fasna M.A., Hamsa N.K., Shukoor C.A., Ajmal T.M., Machado J., Megha G., Divya V., 20252025Kutty S.V., Fasna M.A., Hamsa N.K., Shukoor C.A., Ajmal T.M., Machado J., Megha G., Divya V.Kutty S.V., Fasna M.A., Hamsa N.K., Shukoor C.A., Ajmal T.M., Machado J., Megha G., Divya V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/1823

С помощью УФ-видимой спектроскопии изучена эффективность таблеток телмисартана после истечения срока годности на основе исследования растворимости препарата в метаноле и последующего разбавления водой для получения максимума поглощения при 297 нм. При концентрациях 0.8–4 мкг/мл выполняется закон Бера–Ламберта, с помощью регрессионного анализа найден коэффициент корреляции 0.999. Предложенная методика применена для исследования эффективности таблеток телмисартана двух различных марок после истечения срока годности. Показано, что таблетки телмисартана продолжают действовать после истечения срока годности. Предварительные эксперименты по растворению проведены на электролабораторном тестере при температуре 37°C. Результаты анализа не показали заметного изменения концентрации препарата, что позволяет предположить, что формула таблеток телмисартана не меняется с течением времени Процент высвобождения препарата для таблеток с неистекшим сроком годности, установленный в ходе эксперимента, — 99%, для просроченных — 90%.

This study used UV–visible spectroscopy to investigate the effectiveness of telmisartan tablets after their shelf life, employing the solubility of the drug in methanol and subsequent dilution with water to obtain an absorption maximum at 297 nm. At concentrations ranging from 0.8–4 µg/mL, the study complied with the Beer–Lambert law, and regression analysis revealed a strong correlation coefficient of 0.999. The suggested technique was found to be easy to follow, accurate, precise, and specific when applied to the analysis of tablet formulations. The developed method was validated. To study the post-shelf-life efficacy of telmisartan tablets utilizing two different brands of marketed tablets, the developed technique was followed. The results show that both expired and unexpired telmisartan tablets continue to be useful after their shelf life. The preliminary dissolution tests were performed on an electro-lab dissolution tester at 37°C. The results of the analysis showed no appreciable change in the drug concentration, suggesting that the telmisartan tablet formulation might be stable over time. The percentage release of non-expired tablets observed in the test was 99%, whereas the percentage of expired tablets was 90%.

срок годностителмисартанУФ-спектроскопиярастворениевалидацияpost shelf-life studiestelmisartanUV spectroscopydissolutionmethod validationReferencesIndian Pharmacopoeia, volume II, Govt of India; Ministry of Health and Family Welfare Published by Indian Pharmacopoeia Commission Ghaziabad, 8, 3320 (2018).Indian Pharmacopoeia, volume II, Govt of India; Ministry of Health and Family Welfare Published by Indian Pharmacopoeia Commission Ghaziabad, 8, 3320 (2018).Niranjan D. Chivate, Siddharth M. Patil, Jagdish K. Saboji, N. Anuradha, J. Pharm. Res., 5, N 6, 3331–3333 (2012).Niranjan D. Chivate, Siddharth M. Patil, Jagdish K. Saboji, N. Anuradha, J. Pharm. Res., 5, N 6, 3331–3333 (2012).Rupali B. Giri, Shailesh J. Wadher, Tukaram M. Kalyankar, Indian Drugs, 60, N 10, 58–63 (2021).Rupali B. Giri, Shailesh J. Wadher, Tukaram M. Kalyankar, Indian Drugs, 60, N 10, 58–63 (2021).International Conference on Harmonization of Technical Requirements for Pharmaceuticals for Human Use, ICH Harmonized Guideline, Validation of Analytical Procedures Q2 (R2). Endorsed on 24 March 2022 (2022).International Conference on Harmonization of Technical Requirements for Pharmaceuticals for Human Use, ICH Harmonized Guideline, Validation of Analytical Procedures Q2 (R2). Endorsed on 24 March 2022 (2022).A. Martin, In: Physical Pharmacy, Baltimore, MD: Lippincott Williams and Wilkins, 423–454 (2001).A. Martin, In: Physical Pharmacy, Baltimore, MD: Lippincott Williams and Wilkins, 423–454 (2001).Bagwan Wasim, Bagwan Jasmin, Khan Juber, Shaikh Shehzad, Shaikh Aaqueeb, Dr. G J. Khan. Formulation and Evaluation of Telmisartan Fast Dissolving Tablet by Direct Compression Method. WJPLS, 8, No. 8, 273–277 (2022).Bagwan Wasim, Bagwan Jasmin, Khan Juber, Shaikh Shehzad, Shaikh Aaqueeb, Dr. G J. Khan. Formulation and Evaluation of Telmisartan Fast Dissolving Tablet by Direct Compression Method. WJPLS, 8, No. 8, 273–277 (2022).L. Lachman, H. A. Lieberman, J. L. Kanig, The Theory and Practice of Industrial Pharmacy, 3rd ed., Lippincott Williams &Wilkins, 212–234 (1986).L. Lachman, H. A. Lieberman, J. L. Kanig, The Theory and Practice of Industrial Pharmacy, 3rd ed., Lippincott Williams &Wilkins, 212–234 (1986).S. D. Rathod, P. M. Patel, S. A. Santosh, Waghmare, P. D. Chaudhari, UV-Spectrophotometric Method for Estimation of Telmisartan in Bulk and Tablet Dosage Form IJPSR, 3, No. 10, 3936–3939 (2012).S. D. Rathod, P. M. Patel, S. A. Santosh, Waghmare, P. D. Chaudhari, UV-Spectrophotometric Method for Estimation of Telmisartan in Bulk and Tablet Dosage Form IJPSR, 3, No. 10, 3936–3939 (2012).Ajit Pandey, H. Sawarkar, Mukesh Singh, Dr. P. Kashyap, Priyanka Ghosh, Int. J. Chem. Tech. Res., 3, No. 2, 657–660 (2011).Ajit Pandey, H. Sawarkar, Mukesh Singh, Dr. P. Kashyap, Priyanka Ghosh, Int. J. Chem. Tech. Res., 3, No. 2, 657–660 (2011).Ramya Nagabathula, G. Madhuri, U. Rama Devi, A. Vamsi, K. Bhavani, World J. Pharm. Sci., 7, No. 12, 99–117 (2019).Ramya Nagabathula, G. Madhuri, U. Rama Devi, A. Vamsi, K. Bhavani, World J. Pharm. Sci., 7, No. 12, 99–117 (2019).Komal Patel, Komal Dhudasia, Amit Patel, Jayant Dave, Chaganbhai Patel, Pharm. Methods, 2, No. 4, 253–259 (2011).Komal Patel, Komal Dhudasia, Amit Patel, Jayant Dave, Chaganbhai Patel, Pharm. Methods, 2, No. 4, 253–259 (2011).Muhammad Shahzad Chohan, Mahesh Attimarad, Katharigatta Narayanaswamy venugopala, Anroop Balachandran Nair, Nagaraja Sreeharsha, Efren II Plaza Molina, Ramling Bhagavantrao Kotnal, Sheeba Shafi, Marysheela David, Pottathil Shinu, Abdulrahman Ibrahim Altaysan, Abdulmalek Ahmed Balgoname, Int. J. Environ. Res. Public Health, 19, 7260 (2022).Muhammad Shahzad Chohan, Mahesh Attimarad, Katharigatta Narayanaswamy venugopala, Anroop Balachandran Nair, Nagaraja Sreeharsha, Efren II Plaza Molina, Ramling Bhagavantrao Kotnal, Sheeba Shafi, Marysheela David, Pottathil Shinu, Abdulrahman Ibrahim Altaysan, Abdulmalek Ahmed Balgoname, Int. J. Environ. Res. Public Health, 19, 7260 (2022).Pintu Prajapati, Ankita Patel, Shailesh Shah, J. Chromatogr. Sci., 60, No. 6, 525–537 (2022).Pintu Prajapati, Ankita Patel, Shailesh Shah, J. Chromatogr. Sci., 60, No. 6, 525–537 (2022).

The authors declare that there are no conflicts of interest present.