zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-921Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESРазработка УФ-спектрофотометрических методов определения ризедроната натрия в различных растворахDevelopment of UV Spectrophotometric Methods for the Determination of Risedronate Sodium in Different SolutionsAbdaliT.AbdaliT.

Дамаск

Department of Industrial Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy

Damascus

tala.93.a@gmail.comHasianJ.HasianJ.

Дамаск

Department of Industrial Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy

Damascus

Дамасский университетUniversity of Damascus202110102021885820(1)-820(5)Copyright © Abdali T., Hasian J., 20212021Abdali T., Hasian J.Abdali T., Hasian J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/921

Разработаны четыре простых, чувствительных и точных спектрофотометрических метода определения ризедроната натрия, основанных на чувствительности пиридинила к УФ-излучению при 262 нм, и проверены в соответствии с принципами ICH. Методы показали соответствие закону Бера в диапазонах концентраций 6–120, 5–100, 17–170 и 15–150 мкг/мл, точность для RSD < 2% и воспроизводимость от 90 до 110%.

Four simple, low-cost, sensitive, accurate, and direct spectrophotometric methods for Risedronate sodium (RIS) estimation have been developed. All methods were based on pyridinyl sensitivity for the UV light at 262 nm. The proposed methods were extensively validated according to the ICH guidelines and proved as following Beer's law over the concentration ranges 6–120, 5–100, 17–170, and 15–150 µg/ml for methods 1, 2, 3, and 4, respectively. All the proposed methods were found to be precise with RSD values less than 2% and accurate with recovery values between 90–110%. These methods can fully fill the needs of QC routine tests plus meet different demands for Research and Development departments.

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The authors declare that there are no conflicts of interest present.