zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-924Research ArticleАННОТАЦИИ АНГЛОЯЗЫЧНЫХ СТАТЕЙABSTRACTS ENGLISH-LANGUAGE ARTICLESМоделирование и оптимизация эффективных факторов кинетического спектрофотометрического определения витамина B12Modeling and Optimizing of Effective Factors on Kinetic Spectrophotometric Determination of Vitamin B12KaramiМ.KaramiM.

Йезд

Department of Chemistry, Yazd Branch

Yazd

SafaeiM.SafaeiM.

Йезд

Department of Chemistry, Yazd Branch

Yazd

ShishehboreM. R.ShishehboreM. R.

Йезд

Department of Chemistry, Yazd Branch

Yazd

shishehbor47@gmail.comSheibaniА.SheibaniA.

Йезд

Department of Chemistry, Yazd Branch

Yazd

Исламский университет АзадIslamic Azad University202110102021885824(1)-824(10)Copyright © Karami М., Safaei M., Shishehbore M., Sheibani А., 20212021Karami М., Safaei M., Shishehbore M., Sheibani А.Karami M., Safaei M., Shishehbore M., Sheibani A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/924

Разработан точный, чувствительный и надежный кинетический спектрофотометрический метод определения витамина B12 в биологических образцах и фармацевтических препаратах. Для изучения влияния времени и температуры реакции, реагентов (оранжевого G), концентрации бромноватой и серной кислот при анализе характеристик витамина B12 использован центральнокомпозиционный план методологии поверхности отклика. Витамин B12 оказывает сильное ингибирующее действие на процесс окисления оранжевого G броматом в кислой среде. Широкий линейный динамический диапазон, низкий предел обнаружения и скорость анализа характеризуют предлагаемый метод как новую стратегию определения витамина B12 в биологических и фармацевтических образцах. Созданы линейные полиномиальные математические модели для определения витамина B12. Для оптимальных экспериментальных условий калибровочная кривая линейная в диапазоне 1.0–200.0 мкг/мл. Предел обнаружения витамина B12 0.56 мкг/мл. Статистические сравнения результатов с эталонными методами показывают отличное согласие и не указывают на существенную разницу в точности и прецизионности.

A new, accurate, sensitive, and reliable kinetic spectrophotometric method for the determination of vitamin B12 in biological samples and pharmaceutical formulations has been developed. A central composite design (CCD) of the response surface methodology was used in our research to investigate the effect of reaction time and temperature and the concentration of reagents including orange G, bromate, and sulfuric acid on the assay of vitamin B12. Vitamin B12 shows a strong inhibitory effect on the oxidation of orange G by bromate in acidic media. The wide linear dynamic range, low detection limit, and short time analysis introduce the proposed method as a new strategy for the determination of vitamin B12 in biological and pharmaceutical samples. Also, linear polynomial mathematical models were obtained for the determination of vitamin B12. Under optimum experimental conditions, the calibration curve was linear over the range 1.0–200.0 µg/mL. The limit of detection was 0.56 µg/mL. Statistical comparison of the results with the reference methods shows excellent agreement and indicates no significant difference in accuracy and precision.

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The authors declare that there are no conflicts of interest present.