zhpsЖурнал прикладной спектроскопииZhurnal Prikladnoii Spektroskopii0514-7506B. I. Stepanov Institute of Physics of the National Academy of Scienceszhps-949Research ArticleСтатьиСинтез, строение и антимикробная активность комплексов двухвалентных металлов с 1-нафтилуксусной кислотойSynthesis, structure, and antimicrobial activity of complexes of bivalent metals with 1-naphthylacetic acidAlbedairL. A.AlbedairL. A.

Эр-Рияд 11671

Riyadh 11671

lamiaalbedair@gmail.comНаучный колледж при Университете принцессы Нуры Бинт АбдулрахманDepartment of Chemistry, College of Science at Princess Nourah Bint Abdulrahman University202129112021886973973Copyright © Albedair L.A., 20212021Albedair L.A.Albedair L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://zhps.ejournal.by/jour/article/view/949

Синтезированы и структурно охарактеризованы пять комплексов металлов и синтетического гормона роста растений 1-нафтилуксусной кислоты (C10H7-CH2COOH; HL): [MnL2(H2O)4] (A), [CoL2(H4O)4] (B), [NiL4] (C), [CuL2(H2O)2] (D) и [ZnL2] × H2O (E). Для характеристики комплексов использованы ИК-, 1 Н ЯМР-, УФ-видимая спектроскопия, термогравиметрия, магнитно-резонансный и элементный анализ. Морфологические свойства оценены с помощью методов рентгенографии и сканирующей электронной спектроскопии. Показано, что две L– молекулы скоординированы с ионом металла их бидентатными карбоксилатными группами. Комплексы подвергались скринингу in vitro против нескольких микробов (бактерий и грибков) с использованием метода дисковой диффузии Кирби–Бауэра. Комплекс С проявлял противогрибковую активность против Candida albicans с эффективностью на 15 % выше, чем противогрибковый препарат амфотерицин В. 

1-Naphthylacetic acid (C10H7-CH2COOH; HL) is a synthetic commercial plant hormone widely used in agriculture as a plant growth regulator. Five complexes between metal and this hormone were synthesized and structurally characterized: [MnL2(H2O)2] (A), [CoL2(H2O)2] (B), [NiL2] (C), [CuL2(H2O)2] (D), and [ZnL2] × H2O (E). Next, IR, 1H NMR, UV-Vis, thermogravimetry, magnetic moment, and elemental analyses were used to characterize the complexes, and their morphological properties were assessed using XRD and SEM techniques. These analyses indicated that two L– molecules were coordinated to the metal ion by their bidentate carboxylate groups. Finally, the complexes were screened in vitro against several microbes (bacteria and fungi) using the Kirby–Bauer disc diffusion method. Complex C showed antifungal activity against Candida albicans with a potency that was 15% higher than the antifungal drug amphotericin B. 

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The authors declare that there are no conflicts of interest present.