Influence of Myeloperoxidase and Horseradish Peroxidase on the Fluorescence Characteristics of Graphene Quantum Dots

The fluorescence of graphene quantum dots (GQDs) at various pH, temperature, and ionic strengths, as well as in the absence and in the presence of peroxidases was investigated. It was found that myeloperoxidase and the hypochlorous acid it produces cause GQD degradation in biological systems. The rate of substrate oxidation by horseradish peroxidase and myeloperoxidase was shown to decrease in the presence of GQDs. Fluorescence, biodegradation, and the ability to be functionalized make GQDs the promising components for theranostic platforms.

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