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Accumulation and Visualization of Boron-Nitride Nanoparticles in Glioma Cells
Abstract
We performed the hydrothermal synthesis of biocompatible, fluorescent boron nitride nanoparticles (BNNPs). We found that BNNPs accumulated in rat C6 glioma cells and were visualized upon irradiation at 365 nm. The efficiency of BNNP internalization by cells was found to depend on the incubation time and parameters of the medium. As BNNPs at concentrations up to 1 mg/mL had no cytotoxic effect on the cells, they are promising for the use in bioimaging and boron neutron capture therapy.
Keywords
Supporting agencies: The work was carried out with the financial support of the Belarusian Republican Fund for Fundamental Research (Contract No. X24MP-006)
About the Authors
A. V. Bahdanava
Institute for Nuclear Problems, Belarusian State University; International Sakharov Environmental Institute of Belarusian State University
Belarus
Belarus
Minsk
E. I. Venskaya
Institute of Biophysics and Cell Engineering of the
National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
L. M. Lukyanenko
Institute of Biophysics and Cell Engineering of the
National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
E. V. Shamova
Institute of Biophysics and Cell Engineering of the
National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
T. A. Kulahava
Institute for Nuclear Problems, Belarusian State University
Belarus
Belarus
Minsk
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Review
For citations:
Bahdanava A.V., Venskaya E.I., Lukyanenko L.M., Shamova E.V., Kulahava T.A. Accumulation and Visualization of Boron-Nitride Nanoparticles in Glioma Cells. Zhurnal Prikladnoii Spektroskopii. 2026;93(3):400-406. (In Russ.)
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