MULTIVARIATE ANALYSIS OF THE COMPOSITION OF PHARMACEUTICAL PRODUCTS BASED ON TERAHERTZ TIME-DOMAIN SPECTROSCOPY
Abstract
Multivariate methods were applied to the transmission spectra of pharmaceutical products obtained using the fast Fourier transform of the temporal forms of the terahertz electromagnetic field. Successive use of the principal component analysis and linear discriminant analysis allowed us to classify two drugs, and by the independent component analysis to recover the spectrum of the first component in a mixture of three drugs and identify the characteristic feature of the second.
About the Authors
D. A. Borisevich
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Minsk, 220072
Belarus
Minsk, 220072
A. M. Goncharenko
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Minsk, 220072
Belarus
Minsk, 220072
A. V. Lyakhnovich
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Minsk, 220072
Belarus
Minsk, 220072
G. V. Sinitsyn
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Minsk, 220072
Belarus
Minsk, 220072
M. A. Khodasevich
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Minsk, 220072
Belarus
Minsk, 220072
References
1. J. Yao, Y.-Q. Shi, Z.-R. Li, S.-H. Jin. J. Chromatogr., 853 (2007) 254—259
2. S. Trefi, C. Routaboul, S. Hamieh, V. Gilard, M. Malet-Martino, R. Martino. J. Pharm. Biomed. Anal., 47 (2008) 103—113
3. F. E. Dowell, E. B. Maghirang, F. M. Fernandez, P. N. Newton, M. D. Green. J. Pharm. Biomed. Anal., 48 (2008) 1011—1014
4. Y. Roggoa, K. Degardina, P. Margot. Talanta, 81 (2010) 988—995
5. C. Gendrin, Y. Roggo, C. Collet. J. Pharm. Biomed. Anal., 48 (2008) 533—553
6. J. Qin, L. Xie, Yibin Ying. Anal. Chem., 86 (2014) 11750—11757
7. N. Laman, S. Sree Harsha, D. Grischkowsky. Appl. Spectr., 62, N 3 (2008) 319—326
8. N. Odani, Sh. Mohan, E. Kato, H. Feng, Y. Li, M. Nayeem Hossain, J. K. Drennen III, Carl A. Anderson, Europ. J. Pharm. Biopharm., 145 (2019) 35—41
9. P. Bawuah, D. Markl, D. Farrell, M. Evans, A. Portieri, A. Anderson, D. Goodwin, R. Lucas, J. Axel Zeitler. J. Infrared, Millimeter, and Terahertz Waves, 41 (2020) 450—469
10. M. Manfredi, E. Robotti, F. Quasso, E. Mazzucco, G. Calabrese, E. Marengo. Spectrochim. Acta A: Mol. Biomol. Spectrosc., 189 (2018) 427—435
11. A. Tharwat. Applied Computing and Informatics (2020), https://www.emerald.com/insight/content/doi/10.1016/j.aci.2018.08.006/full/pdf?title=independent-component-analysis-an-introduction
12. http://www.teravil.lt/t-spec.php
13. А. М. Гончаренко, Г. В. Синицын, В. Л. Малевич, А. В. Ляхнович. Неразрушающий контроль и диагностика, № 2 (2015), http://science.by/nauka/57/594/
14. В. Л. Малевич, Г. В. Синицын, Н. Н. Розанов. Опт. и спектр., 4 (2019) 667—670
Review
For citations:
Borisevich D.A., Goncharenko A.M., Lyakhnovich A.V., Sinitsyn G.V., Khodasevich M.A. MULTIVARIATE ANALYSIS OF THE COMPOSITION OF PHARMACEUTICAL PRODUCTS BASED ON TERAHERTZ TIME-DOMAIN SPECTROSCOPY. Zhurnal Prikladnoii Spektroskopii. 2021;88(1):144-149. (In Russ.)
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