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Spectrofluorimetric Method for Determination of Solifenacin Succinate in Bulk and in Tablet Formulation
Abstract
A sensitive, reproducible, and cost-effective spectrofluorimetric method was developed for the quantification of solifenacin succinate in bulk and its tablet formulation. The method was validated in accordance with the International Conference on Harmonization guidelines with respect to linearity, accuracy, precision, limit of detection, limit of quantification, and robustness. Excellent linearity was noted in the concentration range of 15.0–95.0 μg/mL with a correlation coefficient (r2) of 0.9961. The limits of detection and quantitation for the proposed method were found to be 1.19 and 3.62 μg/mL, respectively. Excellent recovery of the drug was obtained from its marketed tablet formulation with the proposed method.
Keywords
Supporting agencies: We sincerely thank Cipla Ltd., Mumbai (India) for graciously providing us with the pure samples of solifenacin succinate. This work was supported by the University Grants Commission (UGC), New Delhi, India (Grant No. 36/N/296).
About the Authors
P. Singh
University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University
India
India
Chandigarh
A. Bali
University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University
India
India
Chandigarh
References
1. D. Robinson, L. Cardozo, Expert Rev. Clin. Pharmacol., 2, No. 3, 239–253 (2009).
2. R. Basra, C. Kelleher, Ther. Clin Risk Manag., 4, No. 1, 117–128 (2008).
3. D. Robinson, L. Cardozo, Therapy, 8, No. 6, 691–701 (2011).
4. N. Desai, S. S. Hussen, K. Arumugam, S. G. Vasanthraju, K. Udupan, Int. J. Pharm. Pharm. Sci., 3, No. 1, 70–74 (2011).
5. R. Reddy, R. Sidhaye, A. Sherikar, M. Nadre, M. Krishna, Pharmacophore, 8, No. 2, 11–23 (2017).
6. R. P. Shaik, S. B. Puttagunta, C. K. Bannoth, B. S. R. Challa, ISRN Anal. Chem, 1–5 (2014).
7. V. Bhavana, H. T. Kumar, S. Y. Rao, V. P. K. Rao, Asian J. Pharm. Anal., 9, No. 3, 118–122 (2019).
8. M. C. Damle, P. C. Rokade, Int. J. Pharm. Sci. Res., 8, No. 4, 218–222 (2016).
9. S. R. Krishna, B. M. Rao, N. S. Rao, J. Chromatogr. Sci., 48, No. 10, 807–810 (2010).
10. H. Terada, Y. Hattori, T. Sasaki, M. Otsuka, Int. J. Pharm., 565, 325–332 (2019).
11. B. Rakesh, P. Bhargavi, S. R. Reddy, A. A. Kumar, Int. J. Pharm. Pharm. Sci., 6, No. 10, 190–193 (2014).
12. K. M. Madhu, C. Rambabu, Rasayan J. Chem., 10, No. 4, 1068–1074 (2017).
13. L. Singh, L. S. Nanda, Pharm. Methods, 2, No. 1, 21–24 (2011).
14. G. D. Teja, C. D. Dasu, B. P. Srinivasa, P. Ravisankar, J. Chem. Pharm. Sci., 6, No. 3, 195–198 (2013).
15. P. Dhara, N. Saiyed, S. Desai, Int. J. Pharm. Pharm. Res., 2, No. 4, 175–183 (2015).
16. Y. Srinivasarao, H. Kumar, P. Chiranjivi, V. K. Rao, Indian J. Pharm. Sci., 83, No. 2, 331–335 (2021).
17. B. V. Reddy, B. S. Reddy, N. V. V. S. S. Raman, K. S. Reddy, C. Rambabu, J. Chem., 1–10 (2013).
18. D. Desai, G. Patel, N. Shukla, S. Rajput, Acta Chromatogr., 24, No. 3, 399–418 (2012).
19. M. A. Tantawy, S. A. Weshahy, M. Wadie, M. R. Rezk, Anal. Methods, 12, No. 26, 3368–3375 (2020).
20. D. K. Singh, M. Kurmi, T. Handa, S. Singh, Chromatographia, 79, No. 3-4, 159–168 (2016).
21. J. Macek, P. Ptáček, J. J. Klíma, J. Chromatogr. B, 878, No. 31, 3327–3330 (2010).
22. W. G. Ammari, Trop. J. Pharm. Res., 14, No. 5, 845–851 (2015).
23. T. C. Akman, Y. Kadıoğlu, Bioorg. Med. Chem., 2, 15–23 (2019).
24. T. Yanagihara, T. Aoki, Y. Soeishi, T. Iwatsubo, H. Kamimura, J. Chromatogr. B, 859, No. 2, 241–245 (2007).
25. S. B. Puttagunta, R. P. Shaik, C. K. Bannoth, B. S. R. Challa, B. Z. Awen, J. Anal. Sci. Technol., 5, No. 1, 1–8 (2014).
26. ICH, Validation of analytical procedures: text and methodology Q2 (R1), In International Conference on Harmonization, Geneva, Switzerland 11, 1–13 (2005).
Review
For citations:
Singh P., Bali A. Spectrofluorimetric Method for Determination of Solifenacin Succinate in Bulk and in Tablet Formulation. Zhurnal Prikladnoii Spektroskopii. 2022;89(4):593.
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