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DEVELOPMENT AND VALIDATION OF KINETIC SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VENLAFAXINE HYDROCHLORIDE
Abstract
A kinetic spectrophotometric method that is sensitive and simple has been developed for the quantification of the venlafaxine hydrochloride in bulk as well as in pharmaceutical preparations. In this technique, venlafaxine is oxidized in the presence of alkaline potassium permanganate as an oxidizing agent and sodium hydroxide as a basic medium, and the reaction is carried out at room temperature. Due to the production of a manganate ion, the spectrophotometric measurement was performed at 610 nm. A fixed-time-based approach (15 min) was used to plot calibration graphs. The proposed method was optimized for all the conditions of reaction, whereby the linearity range was found to be 5–30 µg/mL with a limit of detection of 0.07 µg/mL. For the quantification of venlafaxine hydrochloride in a dosage form, the developed method was successfully applied and the percentage recovery was 98.87–100.22%. Statistical comparison was done for the obtained results with those of an official method and no significant differences regarding precision and accuracy were found.
About the Authors
T. H. Kumar Sony
Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences
India
India
Siddipet, Telangana
S. Y. Manjunath
Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences
India
India
Siddipet, Telangana
S. H. Rasheed
Department of Pharmaceutical Analysis, Srikrupa Institute of Pharmaceutical Sciences
India
India
Siddipet, Telangana
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Review
For citations:
Sony T., Manjunath S.Y., Rasheed S.H. DEVELOPMENT AND VALIDATION OF KINETIC SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VENLAFAXINE HYDROCHLORIDE. Zhurnal Prikladnoii Spektroskopii. 2022;89(5):682-687.
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