Photogeneration of Cytotoxic Radicals in Solutions and Cell Membranes Containing Halomethanes to Increase the Efficiency of Antitumor Therapy
Abstract
Enhancement by halomethanes (CCl4, CHBr3) of photosensitized by Zn-tetraphenylporphin and Zn-tetramethylpyridylporphyrin destruction of protein tryptophanils and lipid peroxidation in isolated erythrocyte membranes has been studied. It is shown that the effect is due to photoinduced electron transfer from Zn-porphyrins to halomethanes with the formation of highly reactive halomethyl radicals. Hydrophilic Zn-tetramethylpyridylporphyrin is more active in halomethane-mediated photosensitization of membrane protein damage, while hydrophobic Zn-tetraphenylporphin is more effective in photosensitizing lipid oxidation.
About the Authors
M. P. Tsvirko
University Jan Dlugosha in Czestochowa
Poland
Poland
Czestochowa
V. V. Gurinovich
Greyhills Academy
United States
United States
Tuba City
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Review
For citations:
Tsvirko M.P., Gurinovich V.V. Photogeneration of Cytotoxic Radicals in Solutions and Cell Membranes Containing Halomethanes to Increase the Efficiency of Antitumor Therapy. Zhurnal Prikladnoii Spektroskopii. 2023;90(3):401-405. (In Russ.)
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