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Kinetic Spectrophotometric Method for Determination of Ceftriaxone in Bulk and Vials
Abstract
An ultra-sensitive kinetic spectrophotometric method has been carried out to determine ceftriaxone in a simple and cost-effective manner. The method utilized the catalytic behavior of the drug in accelerating the reaction between iodine and sodium azide. The fixed time method was exploited to select the optimum reaction time and it was found to be 7.0 minutes after the addition of iodine at pH 2.0 using 0.1 M phosphate buffer. Experimental variables that affect the formation of the reaction product were studied and optimized. The method was validated following ICH guidelines and showed excellent linearity within 0.25–2.50 μg/mL at 348 nm. Kinetics of the reaction were investigated and the reaction rate constant was calculated. The method was successfully applied for the analysis of the drug in dosage forms with high selectivity. Comparing the results of the developed approach with the results of the reported spectrophotometric method showed no significant difference with respect to accuracy and precision. The developed method reached a sensitivity 20 folds greater than the reported method. Being selective and sensitive in analysis makes the method a suitable candidate for quality control monitoring of the cited drug.
About the Authors
E. Yosrey
Mansoura University
Egypt
Egypt
Eman Yosrey
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy
Mansoura
H. Elmansi
Mansoura University
Egypt
Egypt
Heba Elmansi
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy
Mansoura
Z. A. Sheribah
Mansoura University
Egypt
Egypt
Zeinab A. Sheribah
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy
Mansoura
M. El-Sayed Metwally
Mansoura University
Egypt
Egypt
Mohammed El-Sayed Metwally
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy
Mansoura
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Review
For citations:
Yosrey E., Elmansi H., Sheribah Z.A., El-Sayed Metwally M. Kinetic Spectrophotometric Method for Determination of Ceftriaxone in Bulk and Vials. Zhurnal Prikladnoii Spektroskopii. 2023;90(6):973.
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