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Raman Spectroscopy and High-Performance Liquid Chromatography as the Methods for Studying Thermal Degradation of Amoxicillin Trihydrate
Abstract
High-performance liquid chromatography (HPLC) and Raman spectroscopy have been used to study the process of thermal degradation of amoxicillin trihydrate at temperature of 60 ºС. It has been established that when the substance is heated for 6 hours, the content of some impurities increases, the amount of which does not exceed 1%. It is shown that both the HPLC method and the Raman spectroscopy method can be used to evaluate the quality of the amoxicillin substance obtained by thermal degradation at 80 ºС.
About the Authors
R. R. Davletshin
A. M. Butlerov Chemical Institute, Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Kazan
R. R. Galeev
Yaroslavl branch of Federal State Budgetary Institution “Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Federal Service for Surveillance in Healthcare”
Russian Federation
Russian Federation
Yaroslavl
I. R. Aryslanov
Yaroslavl branch of Federal State Budgetary Institution “Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Federal Service for Surveillance in Healthcare”
Russian Federation
Russian Federation
Yaroslavl
E. V. Galeeva
FSBI “Information and Methodological Center for Expert Evaluation, Recording and Analysis of Circulation of Medical Products of Roszdravnadzor”
Russian Federation
Russian Federation
Moscow
A. N. Sedov
A. M. Butlerov Chemical Institute, Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Kazan
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Review
For citations:
Davletshin R.R., Galeev R.R., Aryslanov I.R., Galeeva E.V., Sedov A.N. Raman Spectroscopy and High-Performance Liquid Chromatography as the Methods for Studying Thermal Degradation of Amoxicillin Trihydrate. Zhurnal Prikladnoii Spektroskopii. 2024;91(2):257-263. (In Russ.)
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