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Photophysical Properties and Efficiency of Singlet Oxygen Formation by a рH-Sensitive Sensitizer Based on Meso-Tetrakis(4-N-Methylpyridyl)Porphyrin and Hydroxyapatite Nanoparticles
Abstract
The photophysical properties and efficiency of photosensitized singlet oxygen formation by mesotetrakis(4-N-methylpyridyl)porphyrin in a complex with hydroxyapatite nanoparticles were studied. It was shown that, on surface of hydroxyapatite nanoparticles, at least three types of complexes, characterized by different access of oxygen to porphyrin molecules, are formed. It was found that the rotation of the pyridyl substituents of porphyrin in the complex with hydroxyapatite nanoparticles is significantly hindered, while the porphyrin molecules on the surface of the nanoparticles locates in a less polar environment compared to water. The decrease of the quantum yield of the photosensitized singlet oxygen formation by at least 9 times is observed for the porphyrin in the complex with hydroxyapatite nanoparticles. It has been established that the decreasing of the pH to less than 5.0 (pH < 5.0) promotes the release of the porphyrin from hydroxyapatite nanoparticles, while the efficiency of singlet oxygen formation increases, although it does not reach the values characteristic for free porphyrin.
About the Authors
M. V. Parkhats
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
S. V. Lepeshkevich
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
A. V. Petkevich
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
M. V. Verameichyk
Belarusian State University
Belarus
Belarus
Minsk
A. A. Rogachev
Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
S. N. Terekhov
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
D. Tuncel
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center, Bilkent University
Turkey
Turkey
Ankara
B. M. Dzhagarov
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
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Review
For citations:
Parkhats M.V., Lepeshkevich S.V., Petkevich A.V., Verameichyk M.V., Rogachev A.A., Terekhov S.N., Tuncel D., Dzhagarov B.M. Photophysical Properties and Efficiency of Singlet Oxygen Formation by a рH-Sensitive Sensitizer Based on Meso-Tetrakis(4-N-Methylpyridyl)Porphyrin and Hydroxyapatite Nanoparticles. Zhurnal Prikladnoii Spektroskopii. 2024;91(3):335-343. (In Russ.)
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