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Quantification of aprepitant via charge transfer complexation reactions through visible spectrophotometric methods
Abstract
Two spectrophotometric approaches based on charge transfer complexation processes were developed, validated, and deployed for the detection of aprepitants in pharmaceutical dosages. In method A, the aprepitant reacts para chloranilic acid (p-CA) in acetonitrile, resulting in the formation of a purple-colored product. This product exhibited a maximum absorbance at a wavelength of 524 nm. In technique B, the combination of aprepitant and picric acid (PA) in chloroform results in the generation of chromophores having yellow coloration with a peak absorbance at 415 nm. Every experimental parameter was thoroughly examined and fine-tuned to optimize color development. The validation properties of the recommended spectrophotometric approaches, including linearity, range, precision, accuracy, specificity, robustness, detection, and quantification restrictions, were effectively evaluated. Within the concentration range of 10–60 μg/mL, both approaches exhibited a linear relationship with high correlation coefficient values. The suggested that the processes for quantifying aprepitants in dosage form are straightforward, rapid, precise, accurate, and costeffective.
About the Authors
M. Chaitanya
Department of Pharmaceutical Analysis, Bojjam Narasimhlu College of Pharmacy for Women Vinay Nagar
India
India
Saidabad, Hyderabad, Telangana
T. Hemant Kumar
Department of Quality Assurance, School of Pharmacy Technology and Management NMIMS
India
India
Shirpur
S. Koduru
Department of Pharmaceutical Analysis, Bojjam Narasimhlu College of Pharmacy for Women Vinay Nagar
India
India
Saidabad, Hyderabad, Telangana
S. Kalepu
Department of Pharmaceutical Analysis, Bojjam Narasimhlu College of Pharmacy for Women Vinay Nagar
India
India
Saidabad, Hyderabad, Telangana
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Review
For citations:
Chaitanya M., Kumar T., Koduru S., Kalepu S. Quantification of aprepitant via charge transfer complexation reactions through visible spectrophotometric methods. Zhurnal Prikladnoii Spektroskopii. 2024;91(6):922.
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