Analysis of Telmisartan Using UV Spectroscopy in Marketed Samples Post Shelf-Life

Abstract

This study used UV–visible spectroscopy to investigate the effectiveness of telmisartan tablets after their shelf life, employing the solubility of the drug in methanol and subsequent dilution with water to obtain an absorption maximum at 297 nm. At concentrations ranging from 0.8–4 µg/mL, the study complied with the Beer–Lambert law, and regression analysis revealed a strong correlation coefficient of 0.999. The suggested technique was found to be easy to follow, accurate, precise, and specific when applied to the analysis of tablet formulations. The developed method was validated. To study the post-shelf-life efficacy of telmisartan tablets utilizing two different brands of marketed tablets, the developed technique was followed. The results show that both expired and unexpired telmisartan tablets continue to be useful after their shelf life. The preliminary dissolution tests were performed on an electro-lab dissolution tester at 37°C. The results of the analysis showed no appreciable change in the drug concentration, suggesting that the telmisartan tablet formulation might be stable over time. The percentage release of non-expired tablets observed in the test was 99%, whereas the percentage of expired tablets was 90%.