Spectral-Kinetic Characteristics of Photoluminescence of AIS/ZnS-PEI Semiconductor Quantum Dots in Aqueous Solutions and Their Application in Clinical Morphology

Dependence of parameters of time-resolved and steady-state photoluminescence for quantum dots (QD) Ag-In-S2 (AIS) with surface active groups of polyethylenimine (PEI) upon variation of pH of water solutions. It was shown that the high sensitivity of PEI structure to pH in a wide range influences the mobility of charge carriers in AIS QDs and, as a consequence, determines the features of the mechanism of the formation of the dipole moment transition in QDs. Using Stark model and assuming the absence of the electrical field on the QD surface (ZnS shell) in environments with a neutral pH and in ovarian tissues without pathology, it was substantiated that a change in the pH of solutions, both to acidic and alkaline side, causes a change in the electrical field in the local environment of the QD, which manifests itself in changes in the photoluminescence parameters of the QD (band maximum position, intensity, average lifetime). It was found that AIS-PEI QDs under study can act as a contrast agent in clinical morphology. Using confocal microspectrometry, it was shown that AIS-PEI QDs can be used not only for the visualization, but also for screening of ovarian malignancies.

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