OPTIMIZATION OF SPECTRAL RANGE TO ENHANCE THE EFFECTIVENESS OF PHOTOTHERAPY FOR NEONATAL HYPERBILIRUBINEMIA

It is shown that the effectiveness of phototherapy for hyperbilirubinemia of newborns using narrowband LED sources depends not only on the position of the LED emission spectrum peak within the absorption band of bilirubin but also on the width of the spectrum of incident radiation. It has been established that the extension of the spectral range of radiation by adding to the blue light band with l_max » 462 nm a green component with l_max » 505 nm (provided equal integrated power density) results in a more efficient decrease of the total bilirubin level in the blood of newborns. It is assumed that the effect is due to heterogeneity of spectral characteristics of bilirubin in a different microenvironment as well as to the dependence of the optimal wavelength for the pigment photoisomerization on the depth of location of blood vessels where reactions of the bilirubin phototransformation take place. Moreover, the extension of the spectral range of the incident radiation by addition of the green component increases irradiated volumes of blood where the photoisomerization reactions with a high quantum yield of lumirubin formation underlying the therapeutic effect of light upon treatment of hyperbilirubinemia are initiated.

гипербилирубинемия новорожденных, желтуха, двухцветная фототерапия, билирубин, люмирубин, фотоизомеризация, светодиоды, hyperbilirubinemia of newborns, jaundice, phototherapy, bilirubin, lumirubin, photoisomerization, LEDs

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