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Kinetic Spectrophotometric Quantification of Vitamin H in Pristine and Drug Formulations in Micellar Medium
Abstract
A simple, effective, and accurate visible-spectroscopic technique has been established to evaluate vitamin H (VIT-H) in medicinal samples as well as in its pure form. The method depends on the inhibitory influence of VIT-H on the Hg2+-facilitated ligand substitution (LS) reaction between phenylhydrazine (PHZ) and [Fe(CN)6]4–. The strategy involves substituting CN– with PHZ in [Fe(CN)6]4–, resulting in the formation of a [Fe(CN)5 PHZ]3 complex. The VIT-H can be quantified between 0.017 and 1.710 μg/mL by monitoring the absorbance of the complex at 488 nm during the process. The established method enables the detection of VIT-H at concentrations as low as 0.163 μg/mL. Recuperation experiments confirmed the precision and accuracy of the method for VIT-H quantification. The proposed methodology has been successfully employed for the assessment of VIT-H in pure samples and diverse pharmaceuticals, showcasing remarkable accuracy and precision. The results corresponded with the prescribed analytical protocol. The suggested methodology remains unaffected by the excipients typically employed in medications.
About the Authors
Abhishek Srivastava
GLA University
India
India
Department of Chemistry
Mathura, U. P.
Ajaya Bhattarai
M. M. A. M. C., Tribhuvan University
Nepal
Nepal
Department of Chemistry
M. M. A. M. C., Biratnagar
Pradeep Kumar Pandey
Chandighar University
India
India
Department of Chemistry
Unnao, Uttar Pradesh
Neetu Srivastava
D. D. U. Gorakhpur University
India
India
Department of Chemistry
Gorakhpur, U. P.
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For citations:
Srivastava A., Bhattarai A., Pandey P.K., Srivastava N. Kinetic Spectrophotometric Quantification of Vitamin H in Pristine and Drug Formulations in Micellar Medium. Zhurnal Prikladnoii Spektroskopii. 2026;93(1):145/1-145/11.
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