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Spectral Investigations of Inclusion Complexes of the Bifluorophore Fluorescein with α-, β-, and γ-Cyclodextrins
Abstract
The formation of inclusion complexes of the (6-FAM)2 bifluorophore with α-, β-, and γ-cyclodextrins in a phosphate buffer solution (pH 9.0) was studied by spectrophotometry and fluorimetry. The association constants and Gibbs energy changes for 1:1 stoichiometry was determined. The highest association constant was observed for the complex with β-cyclodextrin, which is explained by the optimal spatial match between the guest molecule and the host’s cavity. The effect of the (6-FAM)2/β-CD inclusion complex on the fluorescent response of the system in the presence of protein (bovine serum albumin) is shown.
About the Authors
H. S. Pilipovich
B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
F. Fan
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
I. I. Lisenko
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
V. A. Povedailo
B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
S. A. Tikhomirov
B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
V. V. Shmanai
Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Minsk
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Review
For citations:
Pilipovich H.S., Fan F., Lisenko I.I., Povedailo V.A., Tikhomirov S.A., Shmanai V.V. Spectral Investigations of Inclusion Complexes of the Bifluorophore Fluorescein with α-, β-, and γ-Cyclodextrins. Zhurnal Prikladnoii Spektroskopii. 2026;93(2):238-244. (In Russ.)
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