QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-β-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM
Abstract
A sensitive, rapid, and simple flow-injection chemiluminescence (FI-CL) technique is described for determining cefradine in human urine and capsule samples at the picogram level. The results show that cefradine within 0.1-100.0 nmol/Lquantitatively quenches the CL intensity of the luminol/sulfobutylether-β-cyclodextrin (SBE-β-CD) system, with a relative correlation coefficient r of 0.9931. Subsequently, the possible mechanism for the quenching phenomenon is discussed in detail using the FI-CL and molecular docking methods. The proposed CL method, with a detection limit of 0.03 nmol/L (3σ) and relative standard deviations <3.0% (N = 7), is then implemented to monitor the excretion of cefradine in human urine. After orally administration, the cefradine reaches a maximum value of 1.37 ± 0.02 mg/mL at 2.0 h in urine, and the total excretion is 4.41 ± 0.03 mg/mL within 8.0 h. The absorption rate constant ka, the elimination rate constant ke, and the half-life t1/ 2 are 0.670 ± 0.008 h- 1 , 0.744 ± 0.005 h- 1 , and 0.93 ± 0.05 h, respectively.
About the Authors
M. X. Shen
Institute of Earth Environment, Chinese Academy of Sciences
Russian Federation
Russian Federation
X. J. Tan
College of Earth Sciences and Land Resources, Chang’an University
Russian Federation
Russian Federation
Zh. H. Song
College of Chemistry and Materials Science, Northwest University
Russian Federation
Russian Federation
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Review
For citations:
Shen M.X., Tan X.J., Song Zh.H. QUANTITATIVE MONITORING OF CEFRADINE IN HUMAN URINE USING A LUMINOL/SULFOBUTYLETHER-β-CYCLODEXTRIN CHEMILUMINESCENCE SYSTEM. Zhurnal Prikladnoii Spektroskopii. 2018;85(2):313-320. (In Russ.)
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