RAPID AND SIMPLE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF ANTIVIRAL AND ANTI-PARKINSONISM DRUGS
Abstract
A rapid and sensitive spectrophotometric method has been developed for the quantitative analysis of three antiviral, anti-parkinsonism drugs, namely amantadine (AMA), memantine (MET), and rimantadine (RIM). The method is based on the usage of 1,3-indandione (IDO) as a chromogenic reagent to form charge transfer complexes with the studied drugs and produce colored reaction products with an absorbance maximum at 522 nm, allowing quantitative analysis of these drugs. In addition, the study was validated according to the official guidelines that permits usage in quality control laboratories. Many factors (reagent volume, diluting solvent, temperature, reaction and stability time) influencing the reactions were studied and optimized. The results showed that this method is able to detect AMA, MET, or RIM over a linear range between 10–140 µg/mL with high selectivity and robustness. Furthermore, the study results were applied to analyze the drugs in their pharmaceutical preparations with acceptable accuracy and precision.
About the Authors
M. Oraby
Sohag University
Egypt
Sohag 82524
Egypt
Sohag 82524
A. A. Abdelhamid
Sohag University
Egypt
Sohag 82524
Egypt
Sohag 82524
Kh. M. H. Mohamed
Sohag University
Egypt
Sohag 82524
Egypt
Sohag 82524
A.-H. E. Mehanni
Sohag University
Egypt
Sohag 82524
Egypt
Sohag 82524
M. M. Elsutohy
Al-Azhar University, Assiut branch, Egypt; Schulich School of Engineering, University of Calgary, Canada
Egypt
Egypt
Department of Analytical Chemistry, Faculty of Pharmacy, Assiut 71524, Egypt; Calgary, AB T2N 4V8 Canada
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Review
For citations:
Oraby M., Abdelhamid A.A., Mohamed Kh.M., Mehanni A.E., Elsutohy M.M. RAPID AND SIMPLE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF ANTIVIRAL AND ANTI-PARKINSONISM DRUGS. Zhurnal Prikladnoii Spektroskopii. 2020;87(2):275-281.
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