STUDY OF DEGRADATION KINETIC OF MAGNESIUM OROTATE DIHYDRATE BY SPECTROSCOPIC METHOD
Abstract
In present work we developed and validated five spectrophotometric methods for determination of magnesium orotate dihydrate in distilled water, pH 1.2, 4.5, 6.8, and 7.4 buffer systems. These media were selected to extend the applicability of the developed methods from the development of dosage forms to regular quality control. In all media, linear correlation was observed over the concentration range of 1 to 25 μg/mL. The developed methods were found to be selective and specific to the determination of magnesium orotate dihydrate in the presence of various excipients, as well as accurate, precise, and robust (the percent relative standard deviation was found to be less than 2%, and the percent recoveries were between 98 to 102%). The developed methods were also found to be highly sensitive, since the detection and quantification limits were found to be less than 1 μg/mL. The degradation kinetic studies reveal the stability of magnesium orotate dihydrate against hydrolysis (acidic or basic), oxidation, photolysis, and thermal treatment.
Supporting agencies: The authors would like to thank Overseas Health Care Pvt Ltd. and IKG Punjab Technical University for providing the necessary facilities to carry out this work.
About the Authors
H. Verma
IKG Punjab Technical University; Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy; Overseas R & D Centre, Overseas HealthCare Pvt Ltd.
India
India
Kapurthala
Bela, Ropar, Punjab
Phillaur, Punjab
R. Garg
IKG Punjab Technical University; Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy
India
India
Kapurthala
Bela, Ropar, Punjab
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Review
For citations:
Verma H., Garg R. STUDY OF DEGRADATION KINETIC OF MAGNESIUM OROTATE DIHYDRATE BY SPECTROSCOPIC METHOD. Zhurnal Prikladnoii Spektroskopii. 2020;87(3):479-487.
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