Study of phenylalanine NIR spectra for phenylketonuria determination
Abstract
The aim of this study is to investigate the spectroscopic characteristics of phenylalanine in the NIR spectral range as a preliminary step towards the development of an in vivo method for the determination of phenylalanine in the blood of newborn babies. The first steps in this study included in vitro experiments with mixtures of phenylalanine, saline, and whole blood. Results showed absorption bands in the NIR spectral range that are assigned to overtones of C-H, N-H, and O-H in the range of 1400 to 1700 nm, which together with the melanin absorption lines in the visible spectra range, demonstrate the potential of NIR/VIS spectroscopy as an inexpensive, non-invasive, rapid, and accurate alternative to routine methods for determining of phenylketonuria.
Supporting agencies: The authors thank the students Mrs. Rachel Cohen and Mr. Barak Fidelman for their contribution to this project.
About the Authors
B. Z. Dekel
Ruppin Academic Center, Engineering School at Medical Engineering Department
Israel
EmekHefer.
Israel
EmekHefer.
Y. Cohen
School of Electronic Engineering Institute of Electronics and Mathematics (MIEM HSE) at National Research University Higher School of Economics
Russian Federation
101000 Moscow.
Russian Federation
101000 Moscow.
M. Feldman
Hillel Yaffe Medical Center at Newborn and Neonatal Care Department
Israel
Hadera.
Israel
Hadera.
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Review
For citations:
Dekel B.Z., Cohen Y., Feldman M. Study of phenylalanine NIR spectra for phenylketonuria determination. Zhurnal Prikladnoii Spektroskopii. 2020;87(6):1022(1)-1022(6).
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