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Development and Validation of the Ultraviolet Spectrophotometric Method for Determination of Erlotinib Hydrochloride
Abstract
A simple, accurate, novel, safe, and precise method was developed for the estimation of erlotinib hydrochloride in tablet dosage form using a mixture of methanol and acetonitrile (50:50% V/V). The maximum and subsidiary peak absorption of erlotinib hydrochloride were noted at 247 and 333 nm, respectively. Erlotinib hydrochloride follows Beer’s law in the concentration range of 5–30 μg/mL (r2 = 0.9992). In the proposed method, the subsidiary peak absorption wavelength of 333 nm was used to estimate the concentration of erlotinib hydrochloride in tablets. The linear regression equation was found to be y = 0.0461x + 0.0164. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines, and the values of accuracy, precision, and other statistical variables were found to be in accordance with the prescribed values.
About the Authors
R. A. Jadav
Department of Chemistry and Forensic Science, Bhakta Kavi Narsinh Mehta University, Government Polytechnic Campus
India
India
Khadia, State-Gujarat, India
M. A. Ambasana
Department of Chemistry and Forensic Science, Bhakta Kavi Narsinh Mehta University, Government Polytechnic Campus
India
India
Khadia, State-Gujarat, India
A. H. Bapodra
Department of Chemistry and Forensic Science, Bhakta Kavi Narsinh Mehta University, Government Polytechnic Campus
India
India
Khadia, State-Gujarat, India
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Review
For citations:
Jadav R.A., Ambasana M.A., Bapodra A.H. Development and Validation of the Ultraviolet Spectrophotometric Method for Determination of Erlotinib Hydrochloride. Zhurnal Prikladnoii Spektroskopii. 2022;89(2):369-373.
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