Studies on Spectrophotometric Approach for Analysis of Antiplatelet Therapeutic: Ticagrelor

Abstract

The present research investigates the spectrophotometric approach for the simple and rapid quantification of Ticagrelor in the pharmaceutical matrix using a mathematical filtration technique. The sodium lauryl sulphate (SLS) (5% w/v) eco-sustainable solvent was employed to enhance the spectral absorption of Ticagrelor as an alternative to polar organic solvents in Ticaspan® tablets without any interruption of excipients routinely used in the marketed preparation of the cited drug. Four new analytical spectroscopic approaches such as zero-order and zero-order-area under the curve, first-order, and first-order-area under the curve were formulated and addressed in association with a recommended protocol of the International Conference on Harmonization (ICH), i.e., Q2R1 to quantify the cited therapeutic at 251.20–265.40 nm extended spectral wavelength ranges of UV/Vis-spectrometer unit for 5–30 µg/mL concentration ranges. A comparative study was accomplished among novel experiments; there was no statistical variance between the findings resulting from the present research and those attained by the literature reports subsequently to statistical assessment.