CYTOTOXICITY AND DNA BINDING ABILITY OF TWO NOVEL GOLD(III) COMPLEXES
Abstract
The interaction of two gold(III) complexes [Au(phen)Cl2](Cl) (1) and [Au(pdon)Cl2](Cl) (2) with calf thymus-DNA (CT-DNA) has been investigated by absorption and fluorescence emission. Both complexes 1 and 2 show medium interaction ability with CT-DNA with the intrinsic binding constants Kb of 4.98×105 and 1.98×105 M-1 at room temperature, respectively, which is the same as earlier reports for typical classical intercalators. Moreover, complex 1 demonstrates a better antitumor effect on the tested cancer cells.
Supporting agencies: This work was financially supported by the Qing Lan Project of the Jiangsu Province.
About the Authors
G. Gu
School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University
China
Yancheng, Jiangsu 224051
China
Yancheng, Jiangsu 224051
Ch. Chen
School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University
China
Yancheng, Jiangsu 224051
China
Yancheng, Jiangsu 224051
Q. Wang
School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University
China
Yancheng, Jiangsu 224051
China
Yancheng, Jiangsu 224051
Z. Gao
School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University
China
Yancheng, Jiangsu 224051
China
Yancheng, Jiangsu 224051
M. Xu
School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers’ University
China
Yancheng, Jiangsu 224051
China
Yancheng, Jiangsu 224051
References
1. L. Sleire, H. E. Forde-Tislevoll, I. A. Netland, L. Leiss, B. S. Skeie, P. O. Enger, Pharmacol. Res., 124, 74–91 (2017).
2. B. Jönsson, N. Wilking, J. Cancer Policy, 2, 45–62 (2014).
3. Y. L. Chen, M. C. Chang, W. F. Cheng, Cancer Lett., 400, 282–292 (2017).
4. M. S. Kinch, Drug. Discov. Today, 21, 1046–1050 (2016).
5. J. P. Delord, C. Puozzo, F. Lefresne, R. Bugat, Anticancer Res., 29, 553–560 (2009).
6. D. S. Hsu, B. S. Balakumaran, C. R. Acharya, V. Vlahovic, K. S. Walters, K. Garman, J. Clin. Oncol., 25, 4350–4357 (2007).
7. M. T. Sener, E. Sener, A. Tok, B. Polat, I. Cinar, H. Polat, A. Fatih, S. Halis, Pharmacol. Rep., 64, 594–602 (2012).
8. P. D. Sanchez-Gonzalez, F. J. Lopez-Hernandez, F. Perez Barriocanal, A. I. Morales, J. M. Lopez-Novoa, Nephrol. Dial. Transpl., 26, 3484–3495 (2011).
9. S. I. Sohn, H. K. Rim, Y. H. Kim, J. H. Choi, J. H. Park, J. W. Choi, S. D. Kim, S. Y. Jeong, K. T. Lee, Biol. Pharm. Bull., 34, 1508–1513 (2011).
10. A. A. Fouad, A. I. Al-Sultan, S. M. Refaie, M. T. Yacoubi, Toxicology, 274, 49–56 (2010).
11. R. P. Miller, R. K. Tadagavadi, G. Ramesh, W. B. Reeves, Toxins (Basel), 2, 2490–2518 (2010).
12. C. Zhao, X. Chen, D. Zang, X. Lan, S. Liao, C. Yang, P. Q. Zhang, J. J. Wu, X. F. Li, N. N. Liu, Y. N. Liao, H. B. Huang, X. P. Shi, L. L. Jiang, X. H. Liu, Z. M. He, X. J. Wang, J. B. Liu, Biochem. Pharmacol., 116, 22–38 (2016).
13. T. S. Reddy, S. H. Priver, N. Mirzadeh, S. K. Bhargava, J. Inorg. Biochem., 175, 1–8 (2017).
14. N. P. E. Barry, P. J. Sadler, Chem. Commun., 49, 5106–5131 (2013).
15. G. Gasser, N. Metzler-Nolte, Curr. Opin. Chem. Biol., 16, 84–91 (2012).
16. T. Zou, C. T. Lum, C. N. Lok, J. J. Zhang, C. M. Che, Chem. Soc. Rev., 44, 8786–8801 (2015).
17. F. Trudu, F. Amato, P. Vaňhara, T. Pivetta, E. M. Peña-Méndez, J. Havel, J. Appl. Biomed., 13, 79–103 (2015).
18. S. Medici, M. Peana, V. M. Nurchi, J. I. Lachowicz, G. Crisponi, M. A. Zoroddu, Coordin. Chem. Rev., 284, 329–350 (2015).
19. M. N. Patel, B. S. Bhatt, P. A. Dosi, Inorg. Chem. Commun., 29, 190–193 (2013).
20. T. Zou, C. T. Lum, C. N. Lok, J. J. Zhang, C. M. Che, Chem. Soc. Rev., 44, 8786–8801 (2015).
21. C. T. Lum, Z. F. Yang, H. Y. Li, R. Wai-Yin Sun, S. T. Fan, R. T. Poon, M. C. M. Lin, C. M. Che, H. F. Kuang, Int. J. Cancer, 118, 1527–1538 (2006).
22. C. Marzano, L. Ronconi, F. Chiara, M. C. Giron, I. Faustinelli, P. Cristofori, A. Trevisan, D. Fregona, Int. J. Cancer, 129, 487–496 (2011).
23. A. Casado-Sanchez, C. Martin-Santos, J. M. Padron, R. Mas-Balleste, C. Navarro-Ranninger, J. Alemánc, S. Cabrera, J. Inorg. Biochem., 174, 111–118 (2017).
24. M. F. Tomasello, C. Nardon, V. Lanza, G. Di Natale, N. Pettenuzzo, S. Salmaso, D. Milardi, P. Caliceti, G. Pappalardo, D. Fregona, Eur. J. Med. Chem., 138, 115–127 (2017).
25. M. C. Gimeno, H. Goitia, A. Laguna, M. E. Luque, M. D. Villacampa, C. Sepulveda, M. Meireles, J. Inorg. Biochem., 105, 1373–1382 (2011).
26. B. Alberto, R. M. Pia, S. Guido, G. Chiara, C. Angela, M. Luigi, Coord. Chem. Rev., 253, 1692–1707 (2009).
27. S. Urig, K. Becker, Semin. Cancer Biol., 16, 452–465 (2006).
28. Y. Wang, Q. Y. He, R. W. Sun, C. M. Che, J. F. Chiu, Eur. J. Pharmacol., 554, 113–122 (2007).
29. T. C. Fuchs, P. Hewitt, AAPS J., 13, 615–631 (2011).
30. Q. M. Wang, L. Yang, J. H. Wu, H. Wang, J. L. Song, X. H. Tang, Biometals, 30, No. 1, 17–26 (2017).
31. Q. M. Wang, H. Mao, W. L. Wang, H. M. Zhu, L. H. Dai, Y. L. Chen, X. H. Tang, Biometals, 30, No. 4, 575–587 (2017).
32. S. Satyanarayana, J. C. Dabroniak, J. B. Chaires, Biochemistry, 31, No. 39, 9319–9324 (1992).
33. P. Baldini, M. Belicchi-Ferrari, F. Bisceglie, P. P. Dall’Aglio, G. Pelosi, S. Pinelli, P. Tarasconi, Inorg. Chem., 43, 7170–7179 (2004).
34. A. Silvestri, G. Barone, G. Ruisi, D. Anselmo, S. Riela, V. T. Liver, J. Inorg. Biochem., 101, 841–848 (2007).
35. L. F. Tan, H. Chao, Y. F. Zhou, L. N. Ji, Polyhedron, 26, No. 13, 3029–3036 (2007).
36. H. Li, X. Y. Le, D. W. Pang, H. Deng, Z. H. Xu, Z. H. Lin, J. Inorg. Biochem., 99, No. 11, 2240–2247 (2005).
37. Mudasir, N. Yoshioka, H. Inoue, J. Inorg. Biochem., 77, 239 (1999).
38. P. T. Tamil-Selvi, H. Stoeckli-Evans, M. J. Palaniandavar, Inorg. Biochem., 99, 2110–2118 (2005).
39. A. Gohel, M. B. McCarthy, G. Gronowicz, Endocrinology, 140, 5339–5347 (1999).
40. J. K. Barton, J. M. Goldberg, C. V. Kumar, N. J. Turro, J. Am. Chem. Soc., 108, 2081–2088 (1986).
41. B. D. Wang, Z. Y. Yang, Q. Wang, T. K. Cai, P. Crewdson, Bioorg. Med. Chem., 14, 1880–1888 (2006).
42. H. Laitinen, V. P. Hytonen, V. R. Nordlund, M. S. Kuloma, Cell Mol. Life Sci., 63, 2992–3017 (2006).
Review
For citations:
Gu G., Chen Ch., Wang Q., Gao Z., Xu M. CYTOTOXICITY AND DNA BINDING ABILITY OF TWO NOVEL GOLD(III) COMPLEXES. Zhurnal Prikladnoii Spektroskopii. 2019;86(4):563-568.
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