FLUORESCENCE DETECTION OF GLUTATHIONE USING N-DOPED GRAPHENE QUANTUM DOTS−MnO2 NANOARCHITECTURE
Abstract
We build a novel fluorescence resonance energy transfer (FRET) method based on N-doped graphene quantum dots (NGQDs)-MnO2 nanocomposite for rapid, sensitive detection of glutathione (GSH) levels in human serum. In this strategy, MnO2 nanosheets on the NGQDs surface serve as a quencher. NGQDs fluorescence can make a recovery by the addition of GSH, which can reduce MnO2 to Mn2+, and thus the GSH can be monitored. The MnO2 platform affords minimal background and high sensitivity for detecting GSH in this proposed scheme. Meanwhile, relevant fluorescence on-off-on processes were monitored, and the sensing mechanism was explored.
Supporting agencies: This work is supported by the National Natural Science Foundation of China (21605075; 21365015; 31660491; 31960207) and Natural Science Foundation of Jiang Xi Province 20181BAB203020, and Interdisciplinary Innovation Fund of Nanchang University (IIFNCU, 9166- 27060003-YB17).
About the Authors
Zhi-Mei Li
College of Chemistry, Nanchang University
China
Nanchang 330031
China
Nanchang 330031
Ting Pi
College of Chemistry, Nanchang University
China
Nanchang 330031
China
Nanchang 330031
Ya-Ping Sheng
School of Chemistry and Materials Science, University of Science and Technology of China
China
Hefei 230026
China
Hefei 230026
Xiang-Juan Zheng
College of Chemistry, Nanchang University;
Jiangxi Key Laboratory for Multiscale Interdisciplinary Study
China
Nanchang 330031
China
Nanchang 330031
References
1. M. Xu, T. Liang, M. Shi, H. Chen, Chem. Rev., 113, 3766–3798 (2013).
2. X. Huang, Z. Zeng, H. Zhang, ChSRv, 42, 1934–1946 (2013).
3. M. Chhowalla, H. S. Shin, G. Eda, L.-J. Li, K. P. Loh, H. Zhang, Nature Chem., 5, 263–275 (2013).
4. C. N. R. Rao, A. K. Sood, K. S. Subrahmanyam, A. Govindaraj, Angew. Chem. Int. Ed., 48, 7752–7777 (2009).
5. M. J. Allen, V. C. Tung, R. B. Kaner, Chem. Rev., 110, 132–145 (2009).
6. L. Ponomarenko, F. Schedin, M. Katsnelson, R. Yang, E. Hill, K. Novoselov, A. Geim, Science, 320, N 5874, 356–358 (2008).
7. P. Zhang, Y. Zhuo, Y. Chang, R. Yuan, Y. Chai, Anal. Chem., 87, 10385–10391 (2015).
8. Z. S. Qian, X. Y. Shan, L. J. Chai, J. J. Ma, J. R. Chen, H. Feng, Nanoscale, 6, 5671–5674 (2014).
9. Y. Wang, L. Zhang, R. P. Liang, J. M. Bai, J. D. Qiu, Anal. Chem., 85, 9148–9155 (2013).
10. H. F. Zhao, R. P. Liang, J. W. Wang, J. D. Qiu, Chem. Commun., 51, 12669–12672 (2015).
11. H. Dong, W. Gao, F. Yan, H. Ji, H. Ju, Anal. Chem., 82, 5511–5517 (2010).
12. X. Ran, H. Sun, F. Pu, J. Ren, X. Qu, Chem. Commun., 49, 1079–1081 (2013).
13. S. Li, Y. Li, J. Cao, J. Zhu, L. Fan, X. Li, Anal. Chem., 86, 10201–10207 (2014).
14. Y. Liu, D. Y. Kim, Chem. Commun., 51, 4176–4179 (2015).
15. B. A. Pinaud, Z. Chen, D. N. Abram, T. F. Jaramillo, J. Phys. Chem. C, 115, 11830–11838 (2011).
16. W. Zhai, C. Wang, P. Yu, Y. Wang, L. Mao, Anal. Chem., 86, 12206–12213 (2014).
17. D. He, X. He, K. Wang, X. Yang, X. Yang, X. Li, Z. Zou, Chem. Commun., 50, 11049–11052 (2014).
18. J. Yuan, Y. Cen, X. J. Kong, S. Wu, C. L. Liu, R. Q. Yu, X. Chu, ACS Appl. Mater. Interfaces, 7, 10548–10555 (2015).
19. Y. Wang, K. Jiang, J. Zhu, L. Zhang, H. Lin, Chem. Commun., 51, 12748–12751 (2015).
20. X. L. Zhang, C. Zheng, S. S. Guo, J. Li, H. H. Yang, G. Chen, Anal. Chem., 86, 3426–3434 (2014).
21. H. M. Meng, Z. Jin, Y. Lv, C. Yang, X. B. Zhang, W. Tan, R. Q. Yu, Anal. Chem., 86, 12321–12326 (2014).
22. D. Pan, J. Zhang, Z. Li, M. Wu, Adv. Mater., 22, 734–738 (2010).
23. G. Zhao, J. Li, L. Jiang, H. Dong, X. Wang, W. Hu, Chem. Sci., 3, 433–437 (2012).
24. F. Yu, P. Li, B. Wang, K. Han, J. Am. Chem. Soc., 135, 7674–7680 (2013).
25. L. El-Khairy, P. M. Ueland, H. Refsum, I. M. Graham, S. E. Vollset, Circulation, 103, 2544–2549 (2001).
26. Y. Wang, K. Jiang, J. Zhu, L. Zhang, H. Lin, Chem. Commun., 51, 12748–12751 (2015).
27. Y. Yuan, S. Wu, F. Shu, Z. Liu, Chem. Commun., 50, 1095–1097 (2014).
28. R. Deng, X. Xie, M. Vendrell, Y. T. Chang, X. Liu, J. Am. Chem. Soc., 133, 20168–20171 (2011).
29. N. Li, W. Diao, Y. Han, W. Pan, T. Zhang, B. Tang, Chemistry–a Eur. J., 20, 16488–16491 (2014).
30. X. Wang, D. Wang, Y. Guo, C. Yang, X. Liu, A. Iqbal, W. Liu, W. Qin, D. Yan, H. Guo, Biosens. Bioelectron., 77, 299–305 (2016).
31. Y. Mi, X. Lei, H. Han, J. Liang, L. Liu, Anal. Methods, 10, 4170–4177 (2018).
32. X. Yan, Y. Song, C. Zhu, J. Song, D. Du, X. Su, Y. Lin, ACS Appl. Mater. Interfaces, 8, 21990–21996 (2016).
33. Z. Z. Dong, L. Lu, C. N. Ko, C. Yang, S. Li, M. Y. Lee, C. H. Leung, D. L. Ma, Nanoscale, 9, 4677–4682 (2017).
34. D. Feng, Y. C. Song, W. Shi, X. H. Li, H. M. Ma, Anal. Chem., 85, 6530–6535 (2013).
35. D. Tian, Z. Qian, Y. Xia, C. Zhu, Langmuir, 28, 3945–3951 (2013).
36. F. Michelet, R. Gueguen, P. Leroy, M. Wellman, A. Nicolas, G. Siest, Clin. Chem., 41, 1509–1517 (1995).
37. R. Deicher, F. Ziai, C. Bieglmayer, M. Schillinger, W. H. Horl, J. Am. Soc. Nephrol., 16, 1811–1818 (2005).
Review
For citations:
Li Zh., Pi T., Sheng Ya., Zheng X. FLUORESCENCE DETECTION OF GLUTATHIONE USING N-DOPED GRAPHENE QUANTUM DOTS−MnO2 NANOARCHITECTURE. Zhurnal Prikladnoii Spektroskopii. 2020;87(5):849(1)-849(8).
Views: 246
Email this article 