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Antibacterial and Anticancer Studies of Mononuclear and Binuclear Complexes of Tellurium(IV), Tantalum(V), Selenium(IV), andNiobium(V) Urate by Spectroscopy Methods
Abstract
Novel tellurium(IV), tantalum(V), selenium(IV), and niobium(V) urate complexes were prepared with molar ratios 1:1 and 2:1 (metal:ligand). The uric acid (H4UA) ligand was reacted with TeCU, TaCf, SeCl4, and NbCf metal chlorides in the presence of NaOH to yield mononuclear and binuclear complexes. The mononuclear tellurium (IV) and tantalum(V) complexes formulas [Te(H3UA)(H2O)3(Cl)]-2Cl-2H2O (I) and [Ta(H3UA)(H2O)2(Cl)2]-2Cl-4H2O (II), as well as binuclear selenium(IV) and niobium(V) complexes [Se2(H2UA)(Cl)4] 2Cl 4H2O (III) and [Nb2(H2UA)(Cl)s]-3H2O (IV), were obtained in the presence of NaOH at pH 8-9. The metal complexes were characterized by elemental analyses, FTIR, 1H-NMR, electronic, conductivity, and thermal analyses. In the case of mononuclear complexes, the coordinating sites are the pyrimidine carbonyl oxygen atom of C(6)=O group and imidazole nitrogen of deprotonated N(7)-H. In addition to these coordinating sites, the pyrimidine carbonyl oxygen atom of C(2)=O and pyrimidine nitrogen of deprotonated N(3)-H are involved in coordination in binuclear complexes. The metal urate complexes exhibited six-coordinate geometries, while the binuclear selenium is four-coordinate. The antibacterial and anticancer activities of the urate complexes were investigated. No antibacterial activity was observed in any treatments, except for gram-negative Klebsiella, which showed a slight effect. The metal complexes showed high proportions of cell viability percentage after treatment in both colorectal adenocarcinoma (Caco-2) and breast cancer (MCF-7) cell lines using the neutral red uptake assay.
About the Authors
F. A. Al-Saif
Department of Chemistry, College of Science at Princess Nourah bint Abdulrahman University
Saudi Arabia
Saudi Arabia
Riyadh 11671, Saudi Arabia
J. Y. Al-Humaidi
Department of Chemistry, College of Science at Princess Nourah bint Abdulrahman University
Saudi Arabia
Saudi Arabia
Riyadh 11671, Saudi Arabia
D. N. Binjawhar
Department of Chemistry, College of Science at Princess Nourah bint Abdulrahman University
Saudi Arabia
Saudi Arabia
Riyadh 11671, Saudi Arabia
H. A. Bakhsh
Department of Chemistry, College of Science at Princess Nourah bint Abdulrahman University
Saudi Arabia
Saudi Arabia
Riyadh 11671, Saudi Arabia
M. S. Refat
Department of Chemistry, College of Science at Taif University, Department of Chemistry at Port Said University
Saudi Arabia
Saudi Arabia
Al-Haweiah, Zip Code 21974, Taif, Saudi Arabia
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Review
For citations:
Al-Saif F.A., Al-Humaidi J.Y., Binjawhar D.N., Bakhsh H.A., Refat M.S. Antibacterial and Anticancer Studies of Mononuclear and Binuclear Complexes of Tellurium(IV), Tantalum(V), Selenium(IV), andNiobium(V) Urate by Spectroscopy Methods. Zhurnal Prikladnoii Spektroskopii. 2021;88(2):261-269.
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