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Optical Nanobiosensing of Stibogluconate in Plasma and Urine Using Green Synthesized Fluorescent Carbon Nanodots
Abstract
Fluorescent carbon nanodots were synthetized from garlic peels as optical nanobiosensors for an anti-leishmaniotic stibogluconate drug. The characterization techniques for the synthetized carbon nanodots confirmed its thermal stability, nanosize in the range 2—14 nm, amorphous nature, and the presence of C—O functional groups. The optical sensor, based on the fluorescent nature of carbon nanodots, was developed for the drug nanobiosensor in dosage form and in human biological fluids. The drug was digested to release a pentavalent antimony cation that quenches the fluorescence intensity of carbon nanodots. The extraction method was performed through ion pairing with trinonylamine. The optical sensing was extended to the in vivo analysis of stibogluconate in real human plasma. The sensing of stibogluconate was found to be linear over the range 0.01-0.10 µg/mL with percentage recoveries of 99.25±1.86, and 99.624±1.33 in vials with spiked plasma and in spiked urine.
Supporting agencies: All authors read and approved the final manuscript. This paper is original and is not under consideration by other publication and has not been published elsewhere. The authors declare that they have no competing interest
About the Authors
W. Talaat
Damanhour University
Egypt
Egypt
Damanhour 25111
A. F. Hassan
Damanhour University
Egypt
Egypt
Damanhour 25111
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Review
For citations:
Talaat W., Hassan A.F. Optical Nanobiosensing of Stibogluconate in Plasma and Urine Using Green Synthesized Fluorescent Carbon Nanodots. Zhurnal Prikladnoii Spektroskopii. 2021;88(2):333(1)-333(13).
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