Preview

Zhurnal Prikladnoii Spektroskopii

Advanced search
Open Access Open Access  Restricted Access Subscription Access

Spectrophotometric Method for the Determination of Metoclopramide in Pharmaceutical Dosage Forms

Abstract

A UV-Vis spectrophotometry method was developed for the determination of metoclopramide hydrochloride in pure and several pharmaceutical preparations, such as Permosan tablets, Meclodin syrups, and Plasil ampoules. The method is based on the diazotization reaction of metoclopramide hydrochloride with sodium nitrate and hydrochloric acid to yield the diazonium salt, which is then reacted with 3,5-dimethyl phenol in the presence of sodium hydroxide to form a yellow azo dye. Calibration curves were linear in the range from 0.3 to 6.5 µg/mL, with a correlation coefficient of 0.9993. The limits of detection and quantification were determined and found to be 0.18 and 0.61 µg/mL, respectively. Accuracy and precision were also determined by calculating the relative error, relative standard deviation, and recoveries. No interference was found from additive substances in pharmaceutical preparations. The proposed method has been successfully applied to determine metoclopramide hydrochloride concentrations in different pharmaceutical formulation samples.

About the Authors

S. M. Abbas
College of Education for Pure Science (Ibn Al-Haitham) at University of Baghdad
Iraq

Sumayha M. Abbas - Department of Chemistry



J. M. S. Jamur
College of Education for Pure Science (Ibn Al-Haitham) at University of Baghdad
Iraq

Jasim M. S. Jamur - Department of Chemistry



A. M. Nasif
College of Education for Pure Science (Ibn Al-Haitham) at University of Baghdad
Iraq

Ali M. Nasif - Department of Chemistry



References

1. World Health Organization. WHO Report on Surveillance of Antibiotic Consumption (2018).

2. P. To, Adherence to Medical Plans for Active and Healthy Ageing. (2016), doi: 10.13140/RG.2.1.5114.4804

3. B. Aswani et al., World J. Pharm. Res., 5, 983-999 (2013).

4. T. M. Bakheet, A. J. Doig, BMC Bioinform, 11 (2010).

5. A. M. Anderson et al., Am. J. Health-System Pharm., 76, 175-181 (2019).

6. S. Markland et al., Cross Sec. Stud., 10, 1-12 (2019).

7. M. Hassannezhad, M. Hosseini, M. R. Ganjali, M. Arvand, Chem. Select, 4, 7616-7626 (2019).

8. O. Z. Devi, K. Basavaiah, K. B. Vinay, H. D. Revanasiddappa, J. Food Drug Anal., 20, 454-463 (2012).

9. M. J. Hussan, M. Q. Al-abachi, M. A. Mustafa, Nat. J. Chem., 17, 19-39 (2005).

10. A. Khan et al., Pak. J. Pharm. Sci., 25, 135-140 (2012).

11. A. A.Jawad, K. H. Kadhim, Int. J. Pharm. Pharm. Sci., 5, 294-298 (2013).

12. U. A. Deokate, A. M. Gorde, Int. J. Pharm. Pharm. Sci., 6, 394-397 (2014).

13. N. P. Dudhane, S. S. Vidhate, B. H. Borkar, R. T. Lohiya, M. J. Umekar, J. Pharm. Sci. Res., 2, 48-52 (2010).

14. J. Shah, M. R. Jan, M. A. Khan, S. Amin, J. Anal. Chem, 60, 633-635 (2005).

15. R. Sinan, S. S. Abed, Spectrophotom. Iraq. J. Sci., 50, 136-143 (2009).

16. O. Zenita Devi, K. Basavaiah, K. B. Vinay, H. D. Revanasiddappa, Arab. J. Chem, 9, S64-S72 (2016).

17. M. S.Attia, M. M. Aboaly, Talanta, 82, 78-84 (2010).

18. N. Kahali, J. Khanam, J. Appl. Pharm. Sci., 8, 018-026 (2018).

19. A. N. Alshirifi, M. H. Abbas, Int. J. Chem. Sci., 13, 1093-1108 (2015).

20. M. Yan, H. Li, B. De M.Chen, X. L. Liu, Y. G. Zhu, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 878, 883-887 (2010).

21. H. W. Lee, et al., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 877, 1716-1720 (2009).

22. A.-M. A. Al-Haideri, N. I.Abdulla, I. K. Malih, Iraq. J. Pharm. Sci., 21, 70-77 (2012).


Review

For citations:


Abbas S.M., Jamur J., Nasif A.M. Spectrophotometric Method for the Determination of Metoclopramide in Pharmaceutical Dosage Forms. Zhurnal Prikladnoii Spektroskopii. 2021;88(2):337(1)-337(8).

Views: 273


ISSN 0514-7506 (Print)