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Spectral properties of a benzothiazole dye modified with polyethylene glycol
https://doi.org/10.47612/0514-7506-2021-88-6-852-857
Abstract
The spectral properties of a new benzothiazole dye modified with polyethylene glycol have been investigated. A strong dependence of the fluorescence quantum yield on the viscosity and polarity of the medium has been shown, i.e. the conjugation of the dye with polyethylene glycol does not lead to the loss of the properties of the molecular rotor, while significantly reduces its aggregation. When incorporated into amyloid fibrils, the quantum yield of the dye increases by more than 40 times; the new dye can be regarded as an efficient fluorescent probe for amyloid fibrils detection and research. In this case, not only the intensity, but also the position of the absorption spectrum can be used as a sensitive parameter. The presence of blood plasma proteins (albumins) in the solution has practically no effect on the position of the absorption spectrum and has little effect on the fluorescence intensity of the probe.
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Review
For citations:
Maskevich A.A. Spectral properties of a benzothiazole dye modified with polyethylene glycol. Zhurnal Prikladnoii Spektroskopii. 2021;88(6):852-857. (In Russ.) https://doi.org/10.47612/0514-7506-2021-88-6-852-857
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