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Novel mononuclear zinc(II) complex with niacin: crystal structure, DNA/protein interaction, and cytotoxicity studies
Abstract
A new mononuclear zinc(II) complex Zn(niacin)2(H2O)4 (1) is synthesized. The interaction of 1 with calf thymus-DNA is investigated by UV-Vis and fluorescence spectrometry, and the apparent binding constant (Kapp) value is established as 4.6×105 M–1 . It is found that the quenching mechanism between bovine serum albumin and 1 might be a static quenching procedure with one binding site. Further, the anticancer activity of the complex on three human tumor cells lines (HT29, HepG2, and MCF-7) is studied. The IC50 values of 1 on HT29, HepG2, MCF-7 are 114.1±8, 146.7±14, and 319.2±13 µM, respectively.
About the Authors
C. Zhao
School of Pharmacy, Yancheng Teachers’ University
China
China
Yancheng, Jiangsu, 224051
L. Huang
Department of Thoracic Surgery, Yancheng City No.1 People’s Hospital
China
China
Yancheng, Jiangsu, 224005
Q. Wang
School of Pharmacy, Yancheng Teachers’ University
China
China
Yancheng, Jiangsu, 224051
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Review
For citations:
Zhao C., Huang L., Wang Q. Novel mononuclear zinc(II) complex with niacin: crystal structure, DNA/protein interaction, and cytotoxicity studies. Zhurnal Prikladnoii Spektroskopii. 2021;88(6):972.
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