RAPID DETERMINATION OF TRACE PALLADIUM IN ACTIVE PHARMACEUTICAL INGREDIENTS BY MAGNETIC SOLID-PHASE EXTRACTION AND FLAME ATOMIC ABSORPTION SPECTROMETRY
Abstract
Glutaraldehyde cross-linked magnetic chitosan nanoparticles were synthesized and used as an adsorbent for the dispersive solid-phase extraction of palladium in active pharmaceutical ingredients (APIs) prior to analysis by a flame atomic absorption spectrophotometer. FT-IR, X-ray diffraction, and TEM were used to characterize the adsorbent. Various parameters of experimental performance, such as adsorbent amount, pH, adsorption time, desorption solutions, coexisting ions, and adsorbent reusability, were investigated and optimized. Under the optimized conditions, good linearity was achieved in the 5.0-500 μg/L concentration range, with correlation coefficients of 0.9989. The limit of detection is 2.8 μg/L and the recoveries of spiked samples ranged from 91.7 to 97.6%. It was confirmed that the GMCNs nanocomposite was a promising adsorbing material for extraction and preconcentration of Pd in APIs.
About the Authors
Q. H. Yin
Kunming Jida Pharmaceutical Co., Ltd
Russian Federation
Russian Federation
D. M. Zhu
Kunming University of Science and Technology
Russian Federation
Russian Federation
D. Z. Yang
Kunming University of Science and Technology
Russian Federation
Russian Federation
Q. F. Hu
School of Ethnic Medicine, Yunnan Nationalities University
Russian Federation
Russian Federation
Y. L. Yang
Kunming University of Science and Technology
Russian Federation
Russian Federation
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Review
For citations:
Yin Q.H., Zhu D.M., Yang D.Z., Hu Q.F., Yang Y.L. RAPID DETERMINATION OF TRACE PALLADIUM IN ACTIVE PHARMACEUTICAL INGREDIENTS BY MAGNETIC SOLID-PHASE EXTRACTION AND FLAME ATOMIC ABSORPTION SPECTROMETRY. Zhurnal Prikladnoii Spektroskopii. 2017;84(6):1013(1)-1013(5). (In Russ.)
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